Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
Abstract Background Distinct oral atypical antipsychotics have different effects on autonomic nervous system (ANS) activity. Among them, oral aripiprazole has been linked to dysfunction of the ANS in schizophrenia. Long-acting injectable aripiprazole is a major treatment option for schizophrenia, bu...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-04617-y |
| _version_ | 1827983135702253568 |
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| author | Saki Hattori Akira Suda Ikuko Kishida Masatoshi Miyauchi Yohko Shiraishi Nobuhiko Noguchi Taku Furuno Takeshi Asami Mami Fujibayashi Natsuki Tsujita Chie Ishii Norio Ishii Takashi Saeki Tadashi Fukushima Toshio Moritani Yusuke Saigusa Akitoyo Hishimoto |
| author_facet | Saki Hattori Akira Suda Ikuko Kishida Masatoshi Miyauchi Yohko Shiraishi Nobuhiko Noguchi Taku Furuno Takeshi Asami Mami Fujibayashi Natsuki Tsujita Chie Ishii Norio Ishii Takashi Saeki Tadashi Fukushima Toshio Moritani Yusuke Saigusa Akitoyo Hishimoto |
| author_sort | Saki Hattori |
| collection | DOAJ |
| description | Abstract Background Distinct oral atypical antipsychotics have different effects on autonomic nervous system (ANS) activity. Among them, oral aripiprazole has been linked to dysfunction of the ANS in schizophrenia. Long-acting injectable aripiprazole is a major treatment option for schizophrenia, but the effect of the aripiprazole formulation on ANS activity remains unclear. In this study, we compared ANS activity between oral aripiprazole and aripiprazole once-monthly (AOM) in schizophrenia. Methods Of the 122 patients with schizophrenia who participated in this study, 72 received oral aripiprazole and 50 received AOM as monotherapy. We used power spectral analysis of heart rate variability to assess ANS activity. Results Patients who received oral aripiprazole showed significantly diminished sympathetic nervous activity compared with those who received AOM. Multiple regression analysis revealed that the aripiprazole formulation significantly influenced sympathetic nervous activity. Conclusion Compared with oral aripiprazole, AOM appears to have fewer adverse effects, such as sympathetic nervous dysfunction. |
| first_indexed | 2024-04-09T22:44:02Z |
| format | Article |
| id | doaj.art-a9ad4a02090840b5a585512b85a6d83d |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-09T22:44:02Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-a9ad4a02090840b5a585512b85a6d83d2023-03-22T12:01:02ZengBMCBMC Psychiatry1471-244X2023-03-012311710.1186/s12888-023-04617-yDifferences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophreniaSaki Hattori0Akira Suda1Ikuko Kishida2Masatoshi Miyauchi3Yohko Shiraishi4Nobuhiko Noguchi5Taku Furuno6Takeshi Asami7Mami Fujibayashi8Natsuki Tsujita9Chie Ishii10Norio Ishii11Takashi Saeki12Tadashi Fukushima13Toshio Moritani14Yusuke Saigusa15Akitoyo Hishimoto16Department of Psychiatry, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineDivision of Physical and Health Education, Setsunan UniversityGraduate School of Human and Environmental Studies, Kyoto UniversityFujisawa HospitalFujisawa HospitalAsahinooka HospitalAsahinooka HospitalGraduate School of Human and Environmental Studies, Kyoto UniversityDepartment of Biostatistics, Yokohama City University School of MedicineDepartment of Psychiatry, Yokohama City University School of MedicineAbstract Background Distinct oral atypical antipsychotics have different effects on autonomic nervous system (ANS) activity. Among them, oral aripiprazole has been linked to dysfunction of the ANS in schizophrenia. Long-acting injectable aripiprazole is a major treatment option for schizophrenia, but the effect of the aripiprazole formulation on ANS activity remains unclear. In this study, we compared ANS activity between oral aripiprazole and aripiprazole once-monthly (AOM) in schizophrenia. Methods Of the 122 patients with schizophrenia who participated in this study, 72 received oral aripiprazole and 50 received AOM as monotherapy. We used power spectral analysis of heart rate variability to assess ANS activity. Results Patients who received oral aripiprazole showed significantly diminished sympathetic nervous activity compared with those who received AOM. Multiple regression analysis revealed that the aripiprazole formulation significantly influenced sympathetic nervous activity. Conclusion Compared with oral aripiprazole, AOM appears to have fewer adverse effects, such as sympathetic nervous dysfunction.https://doi.org/10.1186/s12888-023-04617-yautonomic nervous systemschizophrenia, aripiprazolelong-acting injectable aripiprazole |
| spellingShingle | Saki Hattori Akira Suda Ikuko Kishida Masatoshi Miyauchi Yohko Shiraishi Nobuhiko Noguchi Taku Furuno Takeshi Asami Mami Fujibayashi Natsuki Tsujita Chie Ishii Norio Ishii Takashi Saeki Tadashi Fukushima Toshio Moritani Yusuke Saigusa Akitoyo Hishimoto Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia BMC Psychiatry autonomic nervous system schizophrenia, aripiprazole long-acting injectable aripiprazole |
| title | Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia |
| title_full | Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia |
| title_fullStr | Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia |
| title_full_unstemmed | Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia |
| title_short | Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia |
| title_sort | differences in autonomic nervous system activity between long acting injectable aripiprazole and oral aripiprazole in schizophrenia |
| topic | autonomic nervous system schizophrenia, aripiprazole long-acting injectable aripiprazole |
| url | https://doi.org/10.1186/s12888-023-04617-y |
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