FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China
Abstract Background FBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 gene were associated with type 2 diabetes (T2DM) and the risk factors fo...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Hereditas |
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| Online Access: | https://doi.org/10.1186/s41065-021-00191-z |
| _version_ | 1818444025104957440 |
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| author | Shi-Qi Yan Dilare Adi Cheng Liu Meng-Meng Wang Jialin Abuzhalihana Yun Wu Zhen-Yan Fu Yi-Ning Yang Xiao-Mei Li Xiang Xie Fen Liu Bang-Dang Chen Yi-Tong Ma |
| author_facet | Shi-Qi Yan Dilare Adi Cheng Liu Meng-Meng Wang Jialin Abuzhalihana Yun Wu Zhen-Yan Fu Yi-Ning Yang Xiao-Mei Li Xiang Xie Fen Liu Bang-Dang Chen Yi-Tong Ma |
| author_sort | Shi-Qi Yan |
| collection | DOAJ |
| description | Abstract Background FBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 gene were associated with type 2 diabetes (T2DM) and the risk factors for T2DM in Uygur people in Xinjiang, China. Methods A total of 2164 Chinese Uygur subjects (673 T2DM patients and 1491 controls) were recruited for our case–control study, and four SNPs (rs10033601, rs2255137, rs2292743 and rs35311955) of the FBXW7 gene were genotyped using the improved multiplex ligation detection reaction (iMLDR) technique. Results Our study showed that the genotypes using the overdominant model (GA vs AA + GG) of rs10033601 and using the overdominant model (TA vs TT + AA) of rs2292743 were significantly different between T2DM patients and the controls (P = 0.005 and P = 0.012, respectively). After multivariate adjustments for confounders, the rs10033601 and rs2292743 SNPs were still independent risk factors for T2DM [GA vs AA + GG: odds ratio = 1.35, 95% confidence interval (CI) = 1.12–1.64, P = 0.002; TA vs TT + AA: OR = 1.28, 95% CI = 1.06–1.55, P = 0.011]. Participants within the Chinese Uygur populations and who with the GA genotype of rs10033601 and the TA genotype of rs2292743 were associated with significantly elevated glucose levels. Conclusions Our study revealed that both rs10033601 and rs2292743 of the FBXW7 gene were associated with T2DM in the Uygur populations in Xinjiang. |
| first_indexed | 2024-12-14T19:09:22Z |
| format | Article |
| id | doaj.art-a9aebdcfb0484ace92e918661bd97bd8 |
| institution | Directory Open Access Journal |
| issn | 1601-5223 |
| language | English |
| last_indexed | 2024-12-14T19:09:22Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
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| series | Hereditas |
| spelling | doaj.art-a9aebdcfb0484ace92e918661bd97bd82022-12-21T22:50:46ZengBMCHereditas1601-52232021-08-0115811610.1186/s41065-021-00191-zFBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, ChinaShi-Qi Yan0Dilare Adi1Cheng Liu2Meng-Meng Wang3Jialin Abuzhalihana4Yun Wu5Zhen-Yan Fu6Yi-Ning Yang7Xiao-Mei Li8Xiang Xie9Fen Liu10Bang-Dang Chen11Yi-Tong Ma12Department of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityXinjiang Key Laboratory of Cardiovascular Disease ResearchXinjiang Key Laboratory of Cardiovascular Disease ResearchDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityAbstract Background FBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 gene were associated with type 2 diabetes (T2DM) and the risk factors for T2DM in Uygur people in Xinjiang, China. Methods A total of 2164 Chinese Uygur subjects (673 T2DM patients and 1491 controls) were recruited for our case–control study, and four SNPs (rs10033601, rs2255137, rs2292743 and rs35311955) of the FBXW7 gene were genotyped using the improved multiplex ligation detection reaction (iMLDR) technique. Results Our study showed that the genotypes using the overdominant model (GA vs AA + GG) of rs10033601 and using the overdominant model (TA vs TT + AA) of rs2292743 were significantly different between T2DM patients and the controls (P = 0.005 and P = 0.012, respectively). After multivariate adjustments for confounders, the rs10033601 and rs2292743 SNPs were still independent risk factors for T2DM [GA vs AA + GG: odds ratio = 1.35, 95% confidence interval (CI) = 1.12–1.64, P = 0.002; TA vs TT + AA: OR = 1.28, 95% CI = 1.06–1.55, P = 0.011]. Participants within the Chinese Uygur populations and who with the GA genotype of rs10033601 and the TA genotype of rs2292743 were associated with significantly elevated glucose levels. Conclusions Our study revealed that both rs10033601 and rs2292743 of the FBXW7 gene were associated with T2DM in the Uygur populations in Xinjiang.https://doi.org/10.1186/s41065-021-00191-zFBXW7PolymorphismType 2 diabetes |
| spellingShingle | Shi-Qi Yan Dilare Adi Cheng Liu Meng-Meng Wang Jialin Abuzhalihana Yun Wu Zhen-Yan Fu Yi-Ning Yang Xiao-Mei Li Xiang Xie Fen Liu Bang-Dang Chen Yi-Tong Ma FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China Hereditas FBXW7 Polymorphism Type 2 diabetes |
| title | FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China |
| title_full | FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China |
| title_fullStr | FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China |
| title_full_unstemmed | FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China |
| title_short | FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China |
| title_sort | fbxw7 gene polymorphism is associated with type 2 diabetes in the uygur population in xinjiang china |
| topic | FBXW7 Polymorphism Type 2 diabetes |
| url | https://doi.org/10.1186/s41065-021-00191-z |
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