Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins
Approximately 5–15% of solid tumors metastasizing to the central nervous system metastasize to the leptomeninges. Less common, is metastasis to leptomeningeal meningiomas. These are primarily carcinomas of the breast and lung. Awareness of this phenomenon is critical to the evaluation of meningiomas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/23/5877 |
| _version_ | 1797463499853529088 |
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| author | Mahlon D. Johnson |
| author_facet | Mahlon D. Johnson |
| author_sort | Mahlon D. Johnson |
| collection | DOAJ |
| description | Approximately 5–15% of solid tumors metastasizing to the central nervous system metastasize to the leptomeninges. Less common, is metastasis to leptomeningeal meningiomas. These are primarily carcinomas of the breast and lung. Awareness of this phenomenon is critical to the evaluation of meningiomas, especially since the metastases may be the first indication of an occult tumor elsewhere in the body. Lack of clear demarcation between the metastasis and meningioma parenchyma, as well as histological features similar to the meningioma, may hinder recognition. The mechanisms underlying metastases anchoring and spread along the leptomeninges are not established. However, several cell adhesion molecules are thought to contribute to this phenomenon. E cadherin is a cell adhesion molecule present in meningioma cells. Binding to endothelium by adhesion molecules such as ICAM, B1 integrin, P-selectin, PECAM-1, CXCL12 and SDF-1 have also been proposed as part of the mechanisms underlying breast carcinoma metastases. In addition, the leptomeninges and meningiomas express mesothelin that acts as an anchoring protein coupling with mucin-16. Consequently, metastatic tumor cell mucin and mesothelin may also facilitate the anchoring of metastases to meningiomas. |
| first_indexed | 2024-03-09T17:51:34Z |
| format | Article |
| id | doaj.art-a9af225802644885946af9ad854fbe6a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:51:34Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a9af225802644885946af9ad854fbe6a2023-11-24T10:40:13ZengMDPI AGCancers2072-66942022-11-011423587710.3390/cancers14235877Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating ProteinsMahlon D. Johnson0Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave. Box 626, Rochester, NY 14623, USAApproximately 5–15% of solid tumors metastasizing to the central nervous system metastasize to the leptomeninges. Less common, is metastasis to leptomeningeal meningiomas. These are primarily carcinomas of the breast and lung. Awareness of this phenomenon is critical to the evaluation of meningiomas, especially since the metastases may be the first indication of an occult tumor elsewhere in the body. Lack of clear demarcation between the metastasis and meningioma parenchyma, as well as histological features similar to the meningioma, may hinder recognition. The mechanisms underlying metastases anchoring and spread along the leptomeninges are not established. However, several cell adhesion molecules are thought to contribute to this phenomenon. E cadherin is a cell adhesion molecule present in meningioma cells. Binding to endothelium by adhesion molecules such as ICAM, B1 integrin, P-selectin, PECAM-1, CXCL12 and SDF-1 have also been proposed as part of the mechanisms underlying breast carcinoma metastases. In addition, the leptomeninges and meningiomas express mesothelin that acts as an anchoring protein coupling with mucin-16. Consequently, metastatic tumor cell mucin and mesothelin may also facilitate the anchoring of metastases to meningiomas.https://www.mdpi.com/2072-6694/14/23/5877meningiomatumor-to tumor metastasismesothelincell adhesion molecules |
| spellingShingle | Mahlon D. Johnson Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins Cancers meningioma tumor-to tumor metastasis mesothelin cell adhesion molecules |
| title | Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins |
| title_full | Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins |
| title_fullStr | Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins |
| title_full_unstemmed | Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins |
| title_short | Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins |
| title_sort | metastases to meningiomas a comprehensive literature review including mediating proteins |
| topic | meningioma tumor-to tumor metastasis mesothelin cell adhesion molecules |
| url | https://www.mdpi.com/2072-6694/14/23/5877 |
| work_keys_str_mv | AT mahlondjohnson metastasestomeningiomasacomprehensiveliteraturereviewincludingmediatingproteins |