Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis
Background and purposeWe and others have reported ethnic/race group differences in clinical pain, physical function, and experimental pain sensitivity. However, recent research indicates that with consideration for socioenvironmental factors, ethnicity/race differences become less or non-significant...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Pain Research |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2023.1058476/full |
| _version_ | 1797900377943703552 |
|---|---|
| author | Angela M. Mickle Angela M. Mickle Lisa H. Domenico Jared J. Tanner Ellen L. Terry Ellen L. Terry Josue Cardoso Toni L. Glover Staja Booker Staja Booker Adriana Addison Cesar E. Gonzalez Cynthia S. Garvan David Redden Roland Staud Burel R. Goodin Roger B. Fillingim Kimberly T. Sibille Kimberly T. Sibille Kimberly T. Sibille |
| author_facet | Angela M. Mickle Angela M. Mickle Lisa H. Domenico Jared J. Tanner Ellen L. Terry Ellen L. Terry Josue Cardoso Toni L. Glover Staja Booker Staja Booker Adriana Addison Cesar E. Gonzalez Cynthia S. Garvan David Redden Roland Staud Burel R. Goodin Roger B. Fillingim Kimberly T. Sibille Kimberly T. Sibille Kimberly T. Sibille |
| author_sort | Angela M. Mickle |
| collection | DOAJ |
| description | Background and purposeWe and others have reported ethnic/race group differences in clinical pain, physical function, and experimental pain sensitivity. However, recent research indicates that with consideration for socioenvironmental factors, ethnicity/race differences become less or non-significant. Understanding of factors contributing to pain inequities are needed. Guided by the NIA and NIMHD Health Disparities Research Frameworks, we evaluate the contributions of environmental and behavioral factors on previously reported ethnic/race group differences in: (1) clinical pain, (2) physical function, and (3) experimental pain in individuals with knee pain.MethodsBaseline data from Understanding of Pain and Limitations in Osteoarthritis Disease (UPLOAD) and UPLOAD-2 studies were analyzed. Participants were adults 45 to 85 years old who self-reported as non-Hispanic white (NHW) or black (NHB) with knee pain. A health assessment and quantitative sensory testing were completed. Sociodemographics, environmental, health, clinical and experimental pain, and physical functioning measures were included in nested regressions.ResultsPooled data from 468 individuals, 57 ± 8 years of age, 63% women, and 53% NHB adults. As NHB adults were younger and reported greater socioenvironmental risk than the NHW adults, the term sociodemographic groups is used. With inclusion of recognized environmental and behavioral variables, sociodemographic groups remained a significant predictor accounting for <5% of the variance in clinical pain and physical function and <10% of variance in experimental pain.ConclusionThe incorporation of environmental and behavioral factors reduced relationships between sociodemographic groups and pain-related outcomes. Pain sites, BMI, and income were significant predictors across multiple models. The current study adds to a body of research on the complex array of factors contributing to disparities in pain-related outcomes. |
| first_indexed | 2024-04-10T08:45:01Z |
| format | Article |
| id | doaj.art-a9b20a95c7cf4a9097a2a6058a4d8bf2 |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-04-10T08:45:01Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-a9b20a95c7cf4a9097a2a6058a4d8bf22023-02-22T09:29:53ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2023-02-01410.3389/fpain.2023.10584761058476Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritisAngela M. Mickle0Angela M. Mickle1Lisa H. Domenico2Jared J. Tanner3Ellen L. Terry4Ellen L. Terry5Josue Cardoso6Toni L. Glover7Staja Booker8Staja Booker9Adriana Addison10Cesar E. Gonzalez11Cynthia S. Garvan12David Redden13Roland Staud14Burel R. Goodin15Roger B. Fillingim16Kimberly T. Sibille17Kimberly T. Sibille18Kimberly T. Sibille19College of Medicine, Department of Physical Medicine and Rehabilitation, University of Florida, Gainesville, FL, United StatesCollege of Dentistry, Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, United StatesCollege of Nursing, Department of Biobehavioral Nursing Science, University of Florida, Gainesville, FL, United StatesCollege of Public Health and Health Professionals, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United StatesCollege of Dentistry, Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, United StatesCollege of Nursing, Department of Biobehavioral Nursing Science, University of Florida, Gainesville, FL, United StatesCollege of Dentistry, Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, United StatesSchool of Nursing, Oakland University, Rochester, MI, United StatesCollege of Dentistry, Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, United StatesCollege of Nursing, Department of Biobehavioral Nursing Science, University of Florida, Gainesville, FL, United StatesDepartment of Psychology, College of Arts and Science, University of Birmingham Alabama, Birmingham, AL, United StatesDepartment of Psychology, College of Arts and Science, University of Birmingham Alabama, Birmingham, AL, United StatesCollege of Medicine, Department of Anesthesiology, University of Florida, Gainesville, FL, United StatesDepartment of Biostatistics, School of Public Health, University of Birmingham Alabama, Birmingham, AL, United StatesCollege of Medicine, Department of Rheumatology, University of Florida, Gainesville, FL, United StatesDepartment of Psychology, College of Arts and Science, University of Birmingham Alabama, Birmingham, AL, United StatesCollege of Dentistry, Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, United StatesCollege of Medicine, Department of Physical Medicine and Rehabilitation, University of Florida, Gainesville, FL, United StatesCollege of Dentistry, Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL, United StatesCollege of Medicine, Department of Anesthesiology, University of Florida, Gainesville, FL, United StatesBackground and purposeWe and others have reported ethnic/race group differences in clinical pain, physical function, and experimental pain sensitivity. However, recent research indicates that with consideration for socioenvironmental factors, ethnicity/race differences become less or non-significant. Understanding of factors contributing to pain inequities are needed. Guided by the NIA and NIMHD Health Disparities Research Frameworks, we evaluate the contributions of environmental and behavioral factors on previously reported ethnic/race group differences in: (1) clinical pain, (2) physical function, and (3) experimental pain in individuals with knee pain.MethodsBaseline data from Understanding of Pain and Limitations in Osteoarthritis Disease (UPLOAD) and UPLOAD-2 studies were analyzed. Participants were adults 45 to 85 years old who self-reported as non-Hispanic white (NHW) or black (NHB) with knee pain. A health assessment and quantitative sensory testing were completed. Sociodemographics, environmental, health, clinical and experimental pain, and physical functioning measures were included in nested regressions.ResultsPooled data from 468 individuals, 57 ± 8 years of age, 63% women, and 53% NHB adults. As NHB adults were younger and reported greater socioenvironmental risk than the NHW adults, the term sociodemographic groups is used. With inclusion of recognized environmental and behavioral variables, sociodemographic groups remained a significant predictor accounting for <5% of the variance in clinical pain and physical function and <10% of variance in experimental pain.ConclusionThe incorporation of environmental and behavioral factors reduced relationships between sociodemographic groups and pain-related outcomes. Pain sites, BMI, and income were significant predictors across multiple models. The current study adds to a body of research on the complex array of factors contributing to disparities in pain-related outcomes.https://www.frontiersin.org/articles/10.3389/fpain.2023.1058476/fullhealth disparitiesclinical painphysical functionexperimental painsocial determinants of healthknee osteoarthritis |
| spellingShingle | Angela M. Mickle Angela M. Mickle Lisa H. Domenico Jared J. Tanner Ellen L. Terry Ellen L. Terry Josue Cardoso Toni L. Glover Staja Booker Staja Booker Adriana Addison Cesar E. Gonzalez Cynthia S. Garvan David Redden Roland Staud Burel R. Goodin Roger B. Fillingim Kimberly T. Sibille Kimberly T. Sibille Kimberly T. Sibille Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis Frontiers in Pain Research health disparities clinical pain physical function experimental pain social determinants of health knee osteoarthritis |
| title | Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis |
| title_full | Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis |
| title_fullStr | Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis |
| title_full_unstemmed | Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis |
| title_short | Elucidating factors contributing to disparities in pain-related experiences among adults with or at risk for knee osteoarthritis |
| title_sort | elucidating factors contributing to disparities in pain related experiences among adults with or at risk for knee osteoarthritis |
| topic | health disparities clinical pain physical function experimental pain social determinants of health knee osteoarthritis |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2023.1058476/full |
| work_keys_str_mv | AT angelammickle elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT angelammickle elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT lisahdomenico elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT jaredjtanner elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT ellenlterry elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT ellenlterry elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT josuecardoso elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT tonilglover elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT stajabooker elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT stajabooker elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT adrianaaddison elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT cesaregonzalez elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT cynthiasgarvan elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT davidredden elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT rolandstaud elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT burelrgoodin elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT rogerbfillingim elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT kimberlytsibille elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT kimberlytsibille elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis AT kimberlytsibille elucidatingfactorscontributingtodisparitiesinpainrelatedexperiencesamongadultswithoratriskforkneeosteoarthritis |