Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various Leishmania species possess similar pyrimidine transpo...

Full description

Bibliographic Details
Main Authors:	Khalid J.H. Alzahrani, Juma A.M. Ali, Anthonius A. Eze, Wan Limm Looi, Daniel N.A. Tagoe, Darren J. Creek, Michael P. Barrett, Harry P. de Koning
Format:	Article
Language:	English
Published:	Elsevier 2017-08-01
Series:	International Journal for Parasitology: Drugs and Drug Resistance
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211320716301208

Similar Items

Nucleoside Transport and Nucleobase Uptake Null Mutants in <i>Leishmania mexicana</i> for the Routine Expression and Characterization of Purine and Pyrimidine Transporters
by: Mustafa M. Aldfer, et al.
Published: (2022-07-01)

Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms.
by: Juma A M Ali, et al.
Published: (2013-01-01)

Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors
by: Liudmila A. Alexandrova, et al.
Published: (2022-06-01)

Synthesis and Biological Activity of Reversed Pyrimidine Nucleosides
by: Nataša Župančić, et al.
Published: (2015-03-01)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
by: Alexandra L. Zakharenko, et al.
Published: (2020-08-01)

Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice
by: Avinash K. Persaud, et al.
Published: (2023-06-01)

A Unifying Concept for the Prebiotic Formation of RNA Pyrimidine Nucleosides
by: Jonas Feldmann, et al.
Published: (2023-07-01)

Author Correction: Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice
by: Avinash K. Persaud, et al.
Published: (2023-06-01)

Wavelength dependent excited state dynamics observed in canonical pyrimidine nucleosides
by: Peicong Wu, et al.
Published: (2023-12-01)

A Straightforward Diphenylmethyl Protection Method and Deprotection of Some Pyrimidine Nucleosides
by: Arthur van Aerschot, et al.
Published: (2013-07-01)

Synthesis of Cyclic and Acyclic Pyrimidine Nucleosides Analogues with Anticipated Antiviral Activity
by: Mohamed El-Shehry, et al.
Published: (2018-06-01)

Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives
by: Noha Hasaneen, et al.
Published: (2019-09-01)

The Influence of pH on Complexation Process of Copper(II) Phosphoethanolamine to Pyrimidine Nucleosides
by: Malwina Gabryel-Skrodzka, et al.
Published: (2021-08-01)

An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
by: Roger Stromberg, et al.
Published: (2013-10-01)

Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
by: Klaus Peseke, et al.
Published: (2005-08-01)

Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides
by: Anna A. Klimenko, et al.
Published: (2018-10-01)

Biocoordination reactions in copper(II) ions and phosphocholine systems including pyrimidine nucleosides and nucleotides
by: Malwina Gabryel-Skrodzka, et al.
Published: (2023-07-01)

Nucleoside cyclic 3′,5′-phosphorothioates with purine and pyrimidine scaffolds. A chemical minireview
by: Kjell Undheim
Published: (2022-08-01)

Conical intersection dynamics of pyrimidine nucleosides tracked with sub-20-fs UV pulses
by: Borrego-Varillas Rocío, et al.
Published: (2019-01-01)

Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents
by: Md Z. H. Bulbul, et al.
Published: (2021-01-01)

Nucleoside analogues for the treatment of animal trypanosomiasis
by: Dorien Mabille, et al.
Published: (2022-08-01)

Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains
by: Jiang Liu, et al.
Published: (2018-09-01)

Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues
by: Olga V. Andreeva, et al.
Published: (2021-06-01)

Leishmania donovani Nucleoside Hydrolase terminal domains in cross-protective immunotherapy against Leishmania amazonensis murine infection
by: Dirlei eNico, et al.
Published: (2014-06-01)

Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water
by: Samuel J. Roberts, et al.
Published: (2018-10-01)

Maternal pyrimidine nucleoside supplementation regulates fatty acid, amino acid and glucose metabolism of neonatal piglets
by: Lu-min Gao, et al.
Published: (2022-12-01)

A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues
by: Long Min, et al.
Published: (2022-03-01)

Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: A tangible union against chemoresistant cancer
by: Joshi Swapna, et al.
Published: (2011-08-01)

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment
by: Hamza A. A. Elati, et al.
Published: (2023-12-01)

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance
by: Anthonius A. Eze, et al.
Published: (2019-04-01)

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors
by: Yang Yang, et al.
Published: (2018-07-01)

Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites.
by: Melissa Louise Sykes, et al.
Published: (2020-03-01)

F1 Domain of the Leishmania (Leishmania) donovani Nucleoside Hydrolase Promotes a Th1 Response in Leishmania (Leishmania) infantum Cured Patients and in Asymptomatic Individuals Living in an Endemic Area of Leishmaniasis
by: Eugenia Carrillo, et al.
Published: (2017-07-01)

Cross-protective immunity to Leishmania amazonensis is mediated by CD4+ and CD8+-epitopes of Leishmania donovani Nucleoside Hydrolase terminal domains
by: Dirlei eNico, et al.
Published: (2014-05-01)

Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
by: Degrève, B, et al.
Published: (2000)

Myeloprotective efficiency of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antineoplastic chemotherapy
by: Siprov A.V., et al.
Published: (2015-09-01)

Uptake of purines in <it>Plasmodium falciparum</it>-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
by: Ranford-Cartwright Lisa C, et al.
Published: (2010-01-01)

Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases
by: Irina A. Il’icheva, et al.
Published: (2020-04-01)

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters
by: Zachary Lee Johnson, et al.
Published: (2014-07-01)

Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.
by: Van Laethem, K, et al.
Published: (2001)