Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Histone H2A–H2B dimers in nucleosomes contain an acidic patch, a highly electronegative cleft. Here, the authors characterize a family of binuclear ruthenium compounds that selectively target the acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links....
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Bibliographic Details
| Main Authors: |
Gabriela E. Davey,
Zenita Adhireksan,
Zhujun Ma,
Tina Riedel,
Deepti Sharma,
Sivaraman Padavattan,
Daniela Rhodes,
Alexander Ludwig,
Sara Sandin,
Benjamin S. Murray,
Paul J. Dyson,
Curt A. Davey |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-01680-4
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