Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

Histone H2A–H2B dimers in nucleosomes contain an acidic patch, a highly electronegative cleft. Here, the authors characterize a family of binuclear ruthenium compounds that selectively target the acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links....

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Bibliographic Details
Main Authors:	Gabriela E. Davey, Zenita Adhireksan, Zhujun Ma, Tina Riedel, Deepti Sharma, Sivaraman Padavattan, Daniela Rhodes, Alexander Ludwig, Sara Sandin, Benjamin S. Murray, Paul J. Dyson, Curt A. Davey
Format:	Article
Language:	English
Published:	Nature Portfolio 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01680-4

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