Oxidative Stress Levels and DNA Repair Kinetics in Senescent Primary Human Fibroblasts Exposed to Chronic Low Dose Rate of Ionizing Radiation

Oxidative Stress Levels and DNA Repair Kinetics in Senescent Primary Human Fibroblasts Exposed to Chronic Low Dose Rate of Ionizing Radiation

Background: Exposure to low dose rate (LDR) radiation may accelerate aging processes. Previously, we identified numerous LDR-induced pathways involved in oxidative stress (OS) and antioxidant systems, suggesting that these pathways protect against premature senescence (PS). This study aimed to inves...

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Bibliographic Details
Main Authors: Traimate Sangsuwan, Ali Pour Khavari, Evelina Blomberg, Tajanena Romell, Paulo Roberto D'auria Vieira De Godoy, Mats Harms-Ringdahl, Siamak Haghdoost
Format: Article
Language:English
Published: IMR Press 2023-11-01
Series:Frontiers in Bioscience-Landmark
Subjects:
radiation
chronic radiation
low dose rate
premature senescence
replicative senescence
dna repair
radiotherapy
oxidative stress
hmth1
telomere length
extracellular 8-oxo-dg
Online Access:https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811296

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