Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort study
PurposeTo compare the effects of recombinant FSH alfa (rFSH-alfa), rFSH-beta, highly purified human menopausal gonadotropin (HP-hMG) and urinary FSH (uFSH) in women with polycystic ovarian syndrome who have undertaken the GnRH antagonist protocol during IVF/ICSI treatment.MethodA single-center retro...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1309993/full |
| _version_ | 1797316539791179776 |
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| author | Zhengyan Hu Zhengyan Hu Zhengyan Hu Rujun Zeng Rujun Zeng Rui Gao Rui Gao Mingli Chen Mingli Chen Xiumei Liu Xiumei Liu Qiong Zhang Qiong Zhang Lang Qin Lang Qin Xun Zeng Xun Zeng |
| author_facet | Zhengyan Hu Zhengyan Hu Zhengyan Hu Rujun Zeng Rujun Zeng Rui Gao Rui Gao Mingli Chen Mingli Chen Xiumei Liu Xiumei Liu Qiong Zhang Qiong Zhang Lang Qin Lang Qin Xun Zeng Xun Zeng |
| author_sort | Zhengyan Hu |
| collection | DOAJ |
| description | PurposeTo compare the effects of recombinant FSH alfa (rFSH-alfa), rFSH-beta, highly purified human menopausal gonadotropin (HP-hMG) and urinary FSH (uFSH) in women with polycystic ovarian syndrome who have undertaken the GnRH antagonist protocol during IVF/ICSI treatment.MethodA single-center retrospective cohort study including women with PCOS who received the GnRH antagonist protocol from January 2019 to July 2022 was conducted. Patients were divided into rFSH-alfa group, HP-hMG group, uFSH group, and rFSH-beta group, and the number of oocytes retrieved, clinical pregnancy rate of the fresh cycle (primary outcomes), embryo quality, and severe OHSS rate (secondary outcomes) were compared.ResultsNo statistical differences were found among the four groups in fresh cycle clinical pregnancy rate (p=0.426), nor in the subgroup analyses. The HP-hMG group had a smaller number of oocytes retrieved and a higher high-quality D3 embryo rate than the three FSH groups (p<0.05). No statistical differences were found among the four groups in the severe OHSS rate (p=0.083).ConclusionFor women with PCOS undergoing the GnRH antagonist protocol, the clinical pregnancy rates of fresh IVF/ICSI-ET cycle are similar for all four types of Gn. With a lower risk of OHSS and a similar number of high-quality and available embryos, HP-hMG may have an advantage in the PCOS population. |
| first_indexed | 2024-03-08T03:20:48Z |
| format | Article |
| id | doaj.art-a9b90162e2674c09bca49af70234d3b2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T03:20:48Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a9b90162e2674c09bca49af70234d3b22024-02-12T09:56:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.13099931309993Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort studyZhengyan Hu0Zhengyan Hu1Zhengyan Hu2Rujun Zeng3Rujun Zeng4Rui Gao5Rui Gao6Mingli Chen7Mingli Chen8Xiumei Liu9Xiumei Liu10Qiong Zhang11Qiong Zhang12Lang Qin13Lang Qin14Xun Zeng15Xun Zeng16The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaWest China School of Medicine, Sichuan University, Chengdu, Sichuan, ChinaThe Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaThe Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology, Ziyang Maternal and Child Health Care Hospital, Ziyang, Sichuan, ChinaWest China Second University Hospital, Sichuan University, Ziyang Women’s and Children’s Hospital, Ziyang, Sichuan, ChinaDepartment of Obstetrics and Gynecology, Ziyang Maternal and Child Health Care Hospital, Ziyang, Sichuan, ChinaWest China Second University Hospital, Sichuan University, Ziyang Women’s and Children’s Hospital, Ziyang, Sichuan, ChinaDepartment of Obstetrics and Gynecology, Ziyang Maternal and Child Health Care Hospital, Ziyang, Sichuan, ChinaWest China Second University Hospital, Sichuan University, Ziyang Women’s and Children’s Hospital, Ziyang, Sichuan, ChinaThe Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaThe Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaPurposeTo compare the effects of recombinant FSH alfa (rFSH-alfa), rFSH-beta, highly purified human menopausal gonadotropin (HP-hMG) and urinary FSH (uFSH) in women with polycystic ovarian syndrome who have undertaken the GnRH antagonist protocol during IVF/ICSI treatment.MethodA single-center retrospective cohort study including women with PCOS who received the GnRH antagonist protocol from January 2019 to July 2022 was conducted. Patients were divided into rFSH-alfa group, HP-hMG group, uFSH group, and rFSH-beta group, and the number of oocytes retrieved, clinical pregnancy rate of the fresh cycle (primary outcomes), embryo quality, and severe OHSS rate (secondary outcomes) were compared.ResultsNo statistical differences were found among the four groups in fresh cycle clinical pregnancy rate (p=0.426), nor in the subgroup analyses. The HP-hMG group had a smaller number of oocytes retrieved and a higher high-quality D3 embryo rate than the three FSH groups (p<0.05). No statistical differences were found among the four groups in the severe OHSS rate (p=0.083).ConclusionFor women with PCOS undergoing the GnRH antagonist protocol, the clinical pregnancy rates of fresh IVF/ICSI-ET cycle are similar for all four types of Gn. With a lower risk of OHSS and a similar number of high-quality and available embryos, HP-hMG may have an advantage in the PCOS population.https://www.frontiersin.org/articles/10.3389/fendo.2024.1309993/fullpolycystic ovary syndromeGnRH antagonist protocolIVFICSIgonadotropin |
| spellingShingle | Zhengyan Hu Zhengyan Hu Zhengyan Hu Rujun Zeng Rujun Zeng Rui Gao Rui Gao Mingli Chen Mingli Chen Xiumei Liu Xiumei Liu Qiong Zhang Qiong Zhang Lang Qin Lang Qin Xun Zeng Xun Zeng Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort study Frontiers in Endocrinology polycystic ovary syndrome GnRH antagonist protocol IVF ICSI gonadotropin |
| title | Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort study |
| title_full | Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort study |
| title_fullStr | Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort study |
| title_full_unstemmed | Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort study |
| title_short | Effects of different gonadotropin preparations in GnRH antagonist protocol for patients with polycystic ovary syndrome during IVF/ICSI: a retrospective cohort study |
| title_sort | effects of different gonadotropin preparations in gnrh antagonist protocol for patients with polycystic ovary syndrome during ivf icsi a retrospective cohort study |
| topic | polycystic ovary syndrome GnRH antagonist protocol IVF ICSI gonadotropin |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1309993/full |
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