Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms

Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms

The effect of norovirus dose on outcomes such as virus shedding and symptoms after initial infection is not well understood. We performed a secondary analysis of a human challenge study by using Bayesian mixed-effects models. As the dose increased from 4.8 to 4,800 reverse transcription PCR units,...

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Bibliographic Details
Main Authors: Yang Ge, W. Zane Billings, Antone Opekun, Mary Estes, David Graham, Juan Leon, Katia Koelle, Ye Shen, Robert Atmar, Benjamin Lopman, Andreas Handel
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2023-07-01
Series:Emerging Infectious Diseases
Subjects:
norovirus
inoculum dose
virus shedding
kinetics
viruses
foodborne disease
Online Access:https://wwwnc.cdc.gov/eid/article/29/7/23-0117_article

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