Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases
Bone homeostasis refers to the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption and the maintenance of stable bone mass. SIRT3 is a class of mitochondrial protein deacetylase that influences various mitochondrial functions and is involved in the mechanisms u...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1248507/full |
| _version_ | 1797384969197191168 |
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| author | Ke Xu Jing Li Ruiming Wen Bo Chang Yang Cheng Xuejie Yi |
| author_facet | Ke Xu Jing Li Ruiming Wen Bo Chang Yang Cheng Xuejie Yi |
| author_sort | Ke Xu |
| collection | DOAJ |
| description | Bone homeostasis refers to the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption and the maintenance of stable bone mass. SIRT3 is a class of mitochondrial protein deacetylase that influences various mitochondrial functions and is involved in the mechanisms underlying resistance to aging; regulation of bone marrow mesenchymal stem cells, osteoblasts, and osteoclasts; and development of osteoporosis, osteoarthritis, and other bone diseases. Moreover, exercise affects bones through SIRT3. Thus, studies on SIRT3 may provide insights for the treatment of bone diseases. Although SIRT3 can exert multiple effects on bone, the specific mechanism by which it regulates bone homeostasis remains unclear. By evaluating the relevant literature, this review discusses the structure and function of SIRT3, reveals the role and associated mechanisms of SIRT3 in regulating bone homeostasis and mediating bone health during exercise, and highlights the potential pharmacological value of SIRT3 in treating bone diseases. |
| first_indexed | 2024-03-08T21:47:23Z |
| format | Article |
| id | doaj.art-a9ba53dc5c7d4d9cb5916e31ecb97eae |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T21:47:23Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a9ba53dc5c7d4d9cb5916e31ecb97eae2023-12-20T08:22:52ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.12485071248507Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseasesKe Xu0Jing Li1Ruiming Wen2Bo Chang3Yang Cheng4Xuejie Yi5School of Sports Health, Shenyang Sport University, Shenyang, ChinaSchool of Physical Education, Liaoning Normal University, Dalian, ChinaSchool of Sports Health, Shenyang Sport University, Shenyang, ChinaSchool of Sports Health, Shenyang Sport University, Shenyang, ChinaSchool of Sports Health, Shenyang Sport University, Shenyang, ChinaSchool of Sports Health, Shenyang Sport University, Shenyang, ChinaBone homeostasis refers to the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption and the maintenance of stable bone mass. SIRT3 is a class of mitochondrial protein deacetylase that influences various mitochondrial functions and is involved in the mechanisms underlying resistance to aging; regulation of bone marrow mesenchymal stem cells, osteoblasts, and osteoclasts; and development of osteoporosis, osteoarthritis, and other bone diseases. Moreover, exercise affects bones through SIRT3. Thus, studies on SIRT3 may provide insights for the treatment of bone diseases. Although SIRT3 can exert multiple effects on bone, the specific mechanism by which it regulates bone homeostasis remains unclear. By evaluating the relevant literature, this review discusses the structure and function of SIRT3, reveals the role and associated mechanisms of SIRT3 in regulating bone homeostasis and mediating bone health during exercise, and highlights the potential pharmacological value of SIRT3 in treating bone diseases.https://www.frontiersin.org/articles/10.3389/fphar.2023.1248507/fullSIRT3bone homeostasisosteoblastsosteoclastsmotility |
| spellingShingle | Ke Xu Jing Li Ruiming Wen Bo Chang Yang Cheng Xuejie Yi Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases Frontiers in Pharmacology SIRT3 bone homeostasis osteoblasts osteoclasts motility |
| title | Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases |
| title_full | Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases |
| title_fullStr | Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases |
| title_full_unstemmed | Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases |
| title_short | Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases |
| title_sort | role of sirt3 in bone homeostasis and its application in preventing and treating bone diseases |
| topic | SIRT3 bone homeostasis osteoblasts osteoclasts motility |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1248507/full |
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