Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic Cancer
With a five-year survival rate under 9%, pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest tumors. Although the treatment options are slightly improving, PDAC is the second leading cause of cancer related death in 2020 in the US. In addition to a pronounced desmoplastic stroma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2353 |
| _version_ | 1797549900209061888 |
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| author | Claudia Geismann Alexander Arlt |
| author_facet | Claudia Geismann Alexander Arlt |
| author_sort | Claudia Geismann |
| collection | DOAJ |
| description | With a five-year survival rate under 9%, pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest tumors. Although the treatment options are slightly improving, PDAC is the second leading cause of cancer related death in 2020 in the US. In addition to a pronounced desmoplastic stroma reaction, pancreatic cancer is characterized by one of the lowest levels of oxygen availability within the tumor mass and these hypoxic conditions are known to contribute to tumor development and progression. In this context, the major hypoxia associated transcription factor family, HIF, regulates hundreds of genes involved in angiogenesis, metabolism, migration, invasion, immune escape and therapy resistance. Current research implications show, that hypoxia also modulates diverse areas of epigenetic mechanisms like non-coding RNAs, histone modifications or DNA methylation, which cooperate with the hypoxia-induced transcription factors as well as directly regulate the hypoxic response pathways. In this review, we will focus on hypoxia-mediated epigenetic alterations and their impact on pancreatic cancer. |
| first_indexed | 2024-03-10T15:20:57Z |
| format | Article |
| id | doaj.art-a9be00762cdf43f69fe3120c47775756 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:20:57Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a9be00762cdf43f69fe3120c477757562023-11-20T18:28:24ZengMDPI AGCells2073-44092020-10-01911235310.3390/cells9112353Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic CancerClaudia Geismann0Alexander Arlt1Laboratory of Molecular Gastroenterology & Hepatology, Department of Internal Medicine I, UKSH-Campus Kiel, 24105 Kiel, GermanyLaboratory of Molecular Gastroenterology & Hepatology, Department of Internal Medicine I, UKSH-Campus Kiel, 24105 Kiel, GermanyWith a five-year survival rate under 9%, pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest tumors. Although the treatment options are slightly improving, PDAC is the second leading cause of cancer related death in 2020 in the US. In addition to a pronounced desmoplastic stroma reaction, pancreatic cancer is characterized by one of the lowest levels of oxygen availability within the tumor mass and these hypoxic conditions are known to contribute to tumor development and progression. In this context, the major hypoxia associated transcription factor family, HIF, regulates hundreds of genes involved in angiogenesis, metabolism, migration, invasion, immune escape and therapy resistance. Current research implications show, that hypoxia also modulates diverse areas of epigenetic mechanisms like non-coding RNAs, histone modifications or DNA methylation, which cooperate with the hypoxia-induced transcription factors as well as directly regulate the hypoxic response pathways. In this review, we will focus on hypoxia-mediated epigenetic alterations and their impact on pancreatic cancer.https://www.mdpi.com/2073-4409/9/11/2353pancreatic cancerhypoxiaHIFepigeneticsDNA methylationnon-coding RNA |
| spellingShingle | Claudia Geismann Alexander Arlt Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic Cancer Cells pancreatic cancer hypoxia HIF epigenetics DNA methylation non-coding RNA |
| title | Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic Cancer |
| title_full | Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic Cancer |
| title_fullStr | Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic Cancer |
| title_full_unstemmed | Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic Cancer |
| title_short | Coming in the Air: Hypoxia Meets Epigenetics in Pancreatic Cancer |
| title_sort | coming in the air hypoxia meets epigenetics in pancreatic cancer |
| topic | pancreatic cancer hypoxia HIF epigenetics DNA methylation non-coding RNA |
| url | https://www.mdpi.com/2073-4409/9/11/2353 |
| work_keys_str_mv | AT claudiageismann comingintheairhypoxiameetsepigeneticsinpancreaticcancer AT alexanderarlt comingintheairhypoxiameetsepigeneticsinpancreaticcancer |