Inhibition of Angiogenesis and Extracellular Matrix Remodeling: Synergistic Effect of Renin-Angiotensin System Inhibitors and Bevacizumab

Inhibition of Angiogenesis and Extracellular Matrix Remodeling: Synergistic Effect of Renin-Angiotensin System Inhibitors and Bevacizumab

Bevacizumab (Bev) is a humanized vascular endothelial growth factor monoclonal antibody that is used with chemotherapeutic drugs for the treatment of metastatic colorectal cancer (mCRC). Bev-induced hypertension (HT) is the most common adverse reaction during clinical practice. However, at present,...

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Bibliographic Details
Main Authors:	Tianshu Ren, Hui Jia, Qiong Wu, Yan Zhang, Qun Ma, Dong Yao, Xudong Gao, Danni Xie, Zihua Xu, Qingchun Zhao, Yingshi Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Oncology
Subjects:	bevacizumab renin-angiotensin system inhibitors hypertension angiogenesis extracellular matrix components
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.829059/full

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