Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective
The conventional treatment of thoracic tumors includes surgery, anticancer drugs, radiation, and cancer immunotherapy. Light therapy for thoracic tumors has long been used as an alternative; conventional light therapy also called photodynamic therapy (PDT) has been used mainly for early-stage lung c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1662 |
| _version_ | 1797433835533631488 |
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| author | Kohei Matsuoka Mizuki Yamada Mitsuo Sato Kazuhide Sato |
| author_facet | Kohei Matsuoka Mizuki Yamada Mitsuo Sato Kazuhide Sato |
| author_sort | Kohei Matsuoka |
| collection | DOAJ |
| description | The conventional treatment of thoracic tumors includes surgery, anticancer drugs, radiation, and cancer immunotherapy. Light therapy for thoracic tumors has long been used as an alternative; conventional light therapy also called photodynamic therapy (PDT) has been used mainly for early-stage lung cancer. Recently, near-infrared photoimmunotherapy (NIR-PIT), which is a completely different concept from conventional PDT, has been developed and approved in Japan for the treatment of recurrent and previously treated head and neck cancer because of its specificity and effectiveness. NIR-PIT can apply to any target by changing to different antigens. In recent years, it has become clear that various specific and promising targets are highly expressed in thoracic tumors. In combination with these various specific targets, NIR-PIT is expected to be an ideal therapeutic approach for thoracic tumors. Additionally, techniques are being developed to further develop NIR-PIT for clinical practice. In this review, NIR-PIT is introduced, and its potential therapeutic applications for thoracic cancers are described. |
| first_indexed | 2024-03-09T10:22:29Z |
| format | Article |
| id | doaj.art-a9beef9d5d1f4e6a893ded703dece57d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:22:29Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a9beef9d5d1f4e6a893ded703dece57d2023-12-01T21:56:13ZengMDPI AGBiomedicines2227-90592022-07-01107166210.3390/biomedicines10071662Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational PerspectiveKohei Matsuoka0Mizuki Yamada1Mitsuo Sato2Kazuhide Sato3Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20, Daiko, Higashi-ku, Nagoya 461-8673, JapanDepartment of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20, Daiko, Higashi-ku, Nagoya 461-8673, JapanDepartment of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20, Daiko, Higashi-ku, Nagoya 461-8673, JapanRespiratory Medicine, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Chikusa-ku, Nagoya 466-8550, JapanThe conventional treatment of thoracic tumors includes surgery, anticancer drugs, radiation, and cancer immunotherapy. Light therapy for thoracic tumors has long been used as an alternative; conventional light therapy also called photodynamic therapy (PDT) has been used mainly for early-stage lung cancer. Recently, near-infrared photoimmunotherapy (NIR-PIT), which is a completely different concept from conventional PDT, has been developed and approved in Japan for the treatment of recurrent and previously treated head and neck cancer because of its specificity and effectiveness. NIR-PIT can apply to any target by changing to different antigens. In recent years, it has become clear that various specific and promising targets are highly expressed in thoracic tumors. In combination with these various specific targets, NIR-PIT is expected to be an ideal therapeutic approach for thoracic tumors. Additionally, techniques are being developed to further develop NIR-PIT for clinical practice. In this review, NIR-PIT is introduced, and its potential therapeutic applications for thoracic cancers are described.https://www.mdpi.com/2227-9059/10/7/1662near-infrared photoimmunotherapyNIR-PITphototherapythoracic tumorlung cancertarget antigens |
| spellingShingle | Kohei Matsuoka Mizuki Yamada Mitsuo Sato Kazuhide Sato Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective Biomedicines near-infrared photoimmunotherapy NIR-PIT phototherapy thoracic tumor lung cancer target antigens |
| title | Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective |
| title_full | Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective |
| title_fullStr | Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective |
| title_full_unstemmed | Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective |
| title_short | Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective |
| title_sort | near infrared photoimmunotherapy for thoracic cancers a translational perspective |
| topic | near-infrared photoimmunotherapy NIR-PIT phototherapy thoracic tumor lung cancer target antigens |
| url | https://www.mdpi.com/2227-9059/10/7/1662 |
| work_keys_str_mv | AT koheimatsuoka nearinfraredphotoimmunotherapyforthoraciccancersatranslationalperspective AT mizukiyamada nearinfraredphotoimmunotherapyforthoraciccancersatranslationalperspective AT mitsuosato nearinfraredphotoimmunotherapyforthoraciccancersatranslationalperspective AT kazuhidesato nearinfraredphotoimmunotherapyforthoraciccancersatranslationalperspective |