| Summary: | We evaluated the correlation of electrical impedance myography (EIM) measurements of knee muscles composition using Skulpt Chisel<sup>TM</sup> with MRI data retrieved from muscles segmentation. A total of 140 patients (71 females, 52 ± 21 years) underwent knee MRI, EIM with Skulpt<sup>®</sup>, and clinical evaluation (SARC-F questionnaire). MRIs were reviewed to assess the cross-sectional area (CSA) and skeletal muscle index (SMI = CSA/height<sup>2</sup>) of vastus medialis, vastus lateralis, biceps, semimembranosus, and sartorius. We tested the correlations of EIM-derived parameters [body fat-percentage (BF%) and muscle quality] with total CSA, CSA of each muscle, SMI, and SARC-F scores (0–10) using Pearson correlation coefficient. We found medium negative correlation of BF% with SMI (r = −0.430, <i>p</i> < 0.001) and total CSA (r = −0.445, <i>p</i> < 0.001), particularly with biceps (r = −0.479, <i>p</i> < 0.001), sartorius (r = −0.440, <i>p</i> < 0.001), and semimembranosus (r = −0.357, <i>p</i> < 0.001). EIM-derived muscle quality showed small-to-medium positive correlation with MRI measurements, ranging from r = 0.234 of biceps (<i>p</i> = 0.006) to r = 0.302 of total CSA (<i>p</i> < 0.001), except for vastus lateralis (r = 0.014, <i>p</i> = 0.873). SARC-F scores showed small correlations with EIM and MRI data, ranging from r = −0.132 (<i>p</i> = 0.121) with EIM muscle quality to r = −0.288 (<i>p</i> = 0.001) with CSA of vastus medialis. Hence, we observed small-to-medium correlations of muscle parameters derived from Skulpt Chisel<sup>TM</sup> with SARC-F scores and MRI parameters. We recommend using Skulpt Chisel<sup>TM</sup> with caution for assessing knee skeletal muscles composition.
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