Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies
Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs. Nevertheless, the adaptive immune responses of subunit vaccines are still unfavorable, which m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383523000060 |
| _version_ | 1797740870037929984 |
|---|---|
| author | Yingying Hou Min Chen Yuan Bian Xi Zheng Rongsheng Tong Xun Sun |
| author_facet | Yingying Hou Min Chen Yuan Bian Xi Zheng Rongsheng Tong Xun Sun |
| author_sort | Yingying Hou |
| collection | DOAJ |
| description | Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs. Nevertheless, the adaptive immune responses of subunit vaccines are still unfavorable, which may partially be attributed to the immune cascade obstacles and unsatisfactory vaccine design. An extended understanding of the crosstalk between vaccine delivery strategies and immunological mechanisms could provide scientific insight to optimize antigen delivery and improve vaccination efficacy. In this review, we summarized the advanced subunit vaccine delivery technologies from the perspective of vaccine cascade obstacles after administration. The engineered subunit vaccines with lymph node and specific cell targeting ability, antigen cross-presentation, T cell activation properties, and tailorable antigen release patterns may achieve effective immune protection with high precision, efficiency, and stability. We hope this review can provide rational design principles and inspire the exploitation of future subunit vaccines. |
| first_indexed | 2024-03-12T14:18:43Z |
| format | Article |
| id | doaj.art-a9c1063d7b924300b936c6f233bdd899 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-12T14:18:43Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-a9c1063d7b924300b936c6f233bdd8992023-08-20T04:37:47ZengElsevierActa Pharmaceutica Sinica B2211-38352023-08-0113833213338Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategiesYingying Hou0Min Chen1Yuan Bian2Xi Zheng3Rongsheng Tong4Xun Sun5Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Corresponding authors.Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China; Corresponding authors.Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs. Nevertheless, the adaptive immune responses of subunit vaccines are still unfavorable, which may partially be attributed to the immune cascade obstacles and unsatisfactory vaccine design. An extended understanding of the crosstalk between vaccine delivery strategies and immunological mechanisms could provide scientific insight to optimize antigen delivery and improve vaccination efficacy. In this review, we summarized the advanced subunit vaccine delivery technologies from the perspective of vaccine cascade obstacles after administration. The engineered subunit vaccines with lymph node and specific cell targeting ability, antigen cross-presentation, T cell activation properties, and tailorable antigen release patterns may achieve effective immune protection with high precision, efficiency, and stability. We hope this review can provide rational design principles and inspire the exploitation of future subunit vaccines.http://www.sciencedirect.com/science/article/pii/S2211383523000060Subunit vaccineVaccine designLymph node targetingDendritic cell subset targetingB cell modulationAntigen cross-presentation |
| spellingShingle | Yingying Hou Min Chen Yuan Bian Xi Zheng Rongsheng Tong Xun Sun Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies Acta Pharmaceutica Sinica B Subunit vaccine Vaccine design Lymph node targeting Dendritic cell subset targeting B cell modulation Antigen cross-presentation |
| title | Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies |
| title_full | Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies |
| title_fullStr | Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies |
| title_full_unstemmed | Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies |
| title_short | Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies |
| title_sort | advanced subunit vaccine delivery technologies from vaccine cascade obstacles to design strategies |
| topic | Subunit vaccine Vaccine design Lymph node targeting Dendritic cell subset targeting B cell modulation Antigen cross-presentation |
| url | http://www.sciencedirect.com/science/article/pii/S2211383523000060 |
| work_keys_str_mv | AT yingyinghou advancedsubunitvaccinedeliverytechnologiesfromvaccinecascadeobstaclestodesignstrategies AT minchen advancedsubunitvaccinedeliverytechnologiesfromvaccinecascadeobstaclestodesignstrategies AT yuanbian advancedsubunitvaccinedeliverytechnologiesfromvaccinecascadeobstaclestodesignstrategies AT xizheng advancedsubunitvaccinedeliverytechnologiesfromvaccinecascadeobstaclestodesignstrategies AT rongshengtong advancedsubunitvaccinedeliverytechnologiesfromvaccinecascadeobstaclestodesignstrategies AT xunsun advancedsubunitvaccinedeliverytechnologiesfromvaccinecascadeobstaclestodesignstrategies |