Conservation of the structure and function of bacterial tryptophan synthases

Conservation of the structure and function of bacterial tryptophan synthases

Tryptophan biosynthesis is one of the most characterized processes in bacteria, in which the enzymes from Salmonella typhimurium and Escherichia coli serve as model systems. Tryptophan synthase (TrpAB) catalyzes the final two steps of tryptophan biosynthesis in plants, fungi and bacteria. This pyrid...

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Bibliographic Details
Main Authors: Karolina Michalska, Jennifer Gale, Grazyna Joachimiak, Changsoo Chang, Catherine Hatzos-Skintges, Boguslaw Nocek, Stephen E. Johnston, Lance Bigelow, Besnik Bajrami, Robert P. Jedrzejczak, Samantha Wellington, Deborah T. Hung, Partha P. Nag, Stewart L. Fisher, Michael Endres, Andrzej Joachimiak
Format: Article
Language:English
Published: International Union of Crystallography 2019-07-01
Series:IUCrJ
Subjects:
allosteric regulation
crystal structure
enzyme inhibitors
tryptophan
catalysis
structure determination
protein structure
molecular recognition
X-ray crystallography
enzyme mechanisms
drug discovery
tryptophan synthase
Streptococcus pneumoniae
Legionella pneumophila
Francisella tularensis
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252519005955

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