Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats
The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic <i>Saccharomyces boulardii</i> on the male repro...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/2/170 |
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| author | Çiğdem Sevim Erol Akpınar Emrah Hicazi Aksu Ali Doğan Ömür Serkan Yıldırım Mehtap Kara İsmail Bolat Aristides Tsatsakis Robin Mesnage Kirill S. Golokhvast Sevgi Karabulut Uzunçakmak Rabia Nilüfer Ersoylu |
| author_facet | Çiğdem Sevim Erol Akpınar Emrah Hicazi Aksu Ali Doğan Ömür Serkan Yıldırım Mehtap Kara İsmail Bolat Aristides Tsatsakis Robin Mesnage Kirill S. Golokhvast Sevgi Karabulut Uzunçakmak Rabia Nilüfer Ersoylu |
| author_sort | Çiğdem Sevim |
| collection | DOAJ |
| description | The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic <i>Saccharomyces boulardii</i> on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, <i>Saccharomyces boulardii</i> supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system. |
| first_indexed | 2024-03-11T08:04:07Z |
| format | Article |
| id | doaj.art-a9c616ed5ccd415cb84af9cb9538b182 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-11T08:04:07Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-a9c616ed5ccd415cb84af9cb9538b1822023-11-16T23:37:54ZengMDPI AGToxics2305-63042023-02-0111217010.3390/toxics11020170Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male RatsÇiğdem Sevim0Erol Akpınar1Emrah Hicazi Aksu2Ali Doğan Ömür3Serkan Yıldırım4Mehtap Kara5İsmail Bolat6Aristides Tsatsakis7Robin Mesnage8Kirill S. Golokhvast9Sevgi Karabulut Uzunçakmak10Rabia Nilüfer Ersoylu11Department of Medical Pharmacology, Medicine Faculty, Kastamonu University, 37150 Kastamonu, TurkeyDepartment of Medical Pharmacology, Medicine Faculty, Ataturk University, 25240 Erzurum, TurkeyDepartment of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Kastamonu University, 37150 Kastamonu, TurkeyDepartment of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, 25240 Erzurum, TurkeyDepartment of Pathology, Veterinary Medicine Faculty, Atatürk University, 25240 Erzurum, TurkeyDepartment of Pharmeceutical Toxicology, Pharmacy Faculty, Istanbul University, 34452 Istanbul, TurkeyDepartment of Pathology, Veterinary Medicine Faculty, Atatürk University, 25240 Erzurum, TurkeyDepartment of Toxicology & Forensic Sciences, Medicine Faculty, University of Crete, 71003 Heraklion, GreeceDepartment of Medical and Molecular Genetics, King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UKSiberian Federal Scientific Center of Agrobiotechnology RAS, 630501 Krasnoobsk, RussiaHealth Services Vocational School, Bayburt University, 69000 Bayburt, TurkeyDepartment of Medical Pharmacology, Medicine Faculty, Ataturk University, 25240 Erzurum, TurkeyThe potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic <i>Saccharomyces boulardii</i> on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, <i>Saccharomyces boulardii</i> supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.https://www.mdpi.com/2305-6304/11/2/170acetamipridimidaclopridprobiotic<i>Saccharomyces boulardii</i> |
| spellingShingle | Çiğdem Sevim Erol Akpınar Emrah Hicazi Aksu Ali Doğan Ömür Serkan Yıldırım Mehtap Kara İsmail Bolat Aristides Tsatsakis Robin Mesnage Kirill S. Golokhvast Sevgi Karabulut Uzunçakmak Rabia Nilüfer Ersoylu Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats Toxics acetamiprid imidacloprid probiotic <i>Saccharomyces boulardii</i> |
| title | Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats |
| title_full | Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats |
| title_fullStr | Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats |
| title_full_unstemmed | Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats |
| title_short | Reproductive Effects of <i>S. boulardii</i> on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats |
| title_sort | reproductive effects of i s boulardii i on sub chronic acetamiprid and imidacloprid toxicity in male rats |
| topic | acetamiprid imidacloprid probiotic <i>Saccharomyces boulardii</i> |
| url | https://www.mdpi.com/2305-6304/11/2/170 |
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