Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo
Background and Purpose: In the horizontal canal benign paroxysmal positional vertigo (BPPV), cupulolithiasis shows apogeotropic direction changing nystagmus lasting more than 1 min, while canalolithiasis leads to geotropic direction changing nystagmus lasting < 1 min. The difference between c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00176/full |
| _version_ | 1818853242237353984 |
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| author | Takafumi Nakada Saiko Sugiura Yasue Uchida Yasue Uchida Hirokazu Suzuki Masaaki Teranishi Masaaki Teranishi Michihiko Sone |
| author_facet | Takafumi Nakada Saiko Sugiura Yasue Uchida Yasue Uchida Hirokazu Suzuki Masaaki Teranishi Masaaki Teranishi Michihiko Sone |
| author_sort | Takafumi Nakada |
| collection | DOAJ |
| description | Background and Purpose: In the horizontal canal benign paroxysmal positional vertigo (BPPV), cupulolithiasis shows apogeotropic direction changing nystagmus lasting more than 1 min, while canalolithiasis leads to geotropic direction changing nystagmus lasting < 1 min. The difference between cupulolithiasis and canalolithiasis is widely accepted to be the attachment of the displaced otoconia to the cupula of a semicircular canal. Several studies have shown a relationship between BPPV and vitamin D deficiency, but no studies have compared serum levels of vitamin D between canalolithiasis and cupulolithiasis patients. The purpose of this study was to clarify the difference in vitamin D serum level between canalolithiasis and cupulolithiasis of the horizontal canal.Methods: This retrospective study included 20 and 15 patients with canalolithiasis and cupulolithiasis of the horizontal canal, respectively. Serum levels of 25-hydroxyvitamin D [25(OH)D] during the acute phase of BPPV were measured.Results: The mean 25(OH)D serum level in patients with canalolithiasis and cupulolithiasis was 13.2 ± 1.4 and 20.4 ± 1.6 ng/mL, respectively, and the difference was statistically significant (p = 0.0014), also after adjusting for age and sex (p = 0.0351). Eighteen out of 20 (90%) and 5 of 15 (33%) patients were diagnosed with vitamin D deficiency in the canalolithiasis and cupulolithiasis groups, respectively, and this difference was also statistically significant (p = 0.0005).Conclusion: We found that serum vitamin D level in patients with canalolithiasis was significantly lower than that in patients with cupulolithiasis of the horizontal canal. |
| first_indexed | 2024-12-19T07:33:42Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-19T07:33:42Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-a9c692be1e2e4b72949cb37188e0652f2022-12-21T20:30:38ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-03-011010.3389/fneur.2019.00176440844Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional VertigoTakafumi Nakada0Saiko Sugiura1Yasue Uchida2Yasue Uchida3Hirokazu Suzuki4Masaaki Teranishi5Masaaki Teranishi6Michihiko Sone7Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, JapanDepartment of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, JapanDepartment of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, JapanDepartment of Otorhinolaryngology, Aichi Medical University, Nagakute, JapanDepartment of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, JapanDepartment of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, JapanDepartment of Otorhinolaryngology, Nagoya University, Nagoya, JapanDepartment of Otorhinolaryngology, Nagoya University, Nagoya, JapanBackground and Purpose: In the horizontal canal benign paroxysmal positional vertigo (BPPV), cupulolithiasis shows apogeotropic direction changing nystagmus lasting more than 1 min, while canalolithiasis leads to geotropic direction changing nystagmus lasting < 1 min. The difference between cupulolithiasis and canalolithiasis is widely accepted to be the attachment of the displaced otoconia to the cupula of a semicircular canal. Several studies have shown a relationship between BPPV and vitamin D deficiency, but no studies have compared serum levels of vitamin D between canalolithiasis and cupulolithiasis patients. The purpose of this study was to clarify the difference in vitamin D serum level between canalolithiasis and cupulolithiasis of the horizontal canal.Methods: This retrospective study included 20 and 15 patients with canalolithiasis and cupulolithiasis of the horizontal canal, respectively. Serum levels of 25-hydroxyvitamin D [25(OH)D] during the acute phase of BPPV were measured.Results: The mean 25(OH)D serum level in patients with canalolithiasis and cupulolithiasis was 13.2 ± 1.4 and 20.4 ± 1.6 ng/mL, respectively, and the difference was statistically significant (p = 0.0014), also after adjusting for age and sex (p = 0.0351). Eighteen out of 20 (90%) and 5 of 15 (33%) patients were diagnosed with vitamin D deficiency in the canalolithiasis and cupulolithiasis groups, respectively, and this difference was also statistically significant (p = 0.0005).Conclusion: We found that serum vitamin D level in patients with canalolithiasis was significantly lower than that in patients with cupulolithiasis of the horizontal canal.https://www.frontiersin.org/article/10.3389/fneur.2019.00176/fullbenign paroxysmal positional vertigovitamin Dcanalolithiasisgeotropiccupulolithiasisapogeotropic |
| spellingShingle | Takafumi Nakada Saiko Sugiura Yasue Uchida Yasue Uchida Hirokazu Suzuki Masaaki Teranishi Masaaki Teranishi Michihiko Sone Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo Frontiers in Neurology benign paroxysmal positional vertigo vitamin D canalolithiasis geotropic cupulolithiasis apogeotropic |
| title | Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo |
| title_full | Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo |
| title_fullStr | Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo |
| title_full_unstemmed | Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo |
| title_short | Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo |
| title_sort | difference in serum levels of vitamin d between canalolithiasis and cupulolithiasis of the horizontal semicircular canal in benign paroxysmal positional vertigo |
| topic | benign paroxysmal positional vertigo vitamin D canalolithiasis geotropic cupulolithiasis apogeotropic |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00176/full |
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