Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells

Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells

<p>Abstract</p> <p>Background</p> <p>The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several cancers of breast, prostate and bone, where it activates cancer-related genes and promotes invasive proper...

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Bibliographic Details
Main Authors: Tandon Manish, Gokul Karthiga, Ali Syed A, Chen Zujian, Lian Jane, Stein Gary S, Pratap Jitesh
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Molecular Cancer
Subjects:
Lung cancer
Runx2
BMP-3B
Gene silencing
Online Access:http://www.molecular-cancer.com/content/11/1/27

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