Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG
Objective: In the detection of seizure onset zones, arterial spin labeling (ASL) can overcome the limitations of positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG), which is invasive, expensive, and radioactive. PET/magnetic resonance (MR) systems have been introduced that allo...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301918 |
| _version_ | 1819035346821709824 |
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| author | Yi-He Wang Yang An Xiao-Tong Fan Jie Lu Lian-Kun Ren Peng-Hu Wei Bi-Xiao Cui Jia-Lin Du Chao Lu Di Wang Hua-Qiang Zhang Yong-Zhi Shan Guo-Guang Zhao |
| author_facet | Yi-He Wang Yang An Xiao-Tong Fan Jie Lu Lian-Kun Ren Peng-Hu Wei Bi-Xiao Cui Jia-Lin Du Chao Lu Di Wang Hua-Qiang Zhang Yong-Zhi Shan Guo-Guang Zhao |
| author_sort | Yi-He Wang |
| collection | DOAJ |
| description | Objective: In the detection of seizure onset zones, arterial spin labeling (ASL) can overcome the limitations of positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG), which is invasive, expensive, and radioactive. PET/magnetic resonance (MR) systems have been introduced that allow simultaneous performance of ASL and PET, but comparisons of these techniques with stereoelectroencephalography (SEEG) and comparisons among the treatment outcomes of these techniques are still lacking. Here, we investigate the effectiveness of ASL compared with that of SEEG and their outcomes in localizing mesial temporal lobe epilepsy (MTLE) and assess the correlation between simultaneously acquired PET and ASL. Methods: Between October 2016 and August 2017, we retrospectively studied 12 patients diagnosed with pure unilateral MTLE. We extracted and quantitatively computed values for ASL and PET in the bilateral hippocampus. SEEG findings and outcome were considered the gold standard of lateralization. Finally, the bilateral asymmetry index (AI) was calculated to assess the correlation between PET and ASL. Results: Our results showed that hypoperfusion in the hippocampus detected using ASL matched the SEEG-defined epileptogenic zone in this series of patients. The mean normalized voxel value of ASL in the contralateral hippocampus was 0.97 ± 0.19, while in the ipsilateral hippocampus, it was 0.84 ± 0.14. Meanwhile, significantly decreased perfusion and metabolism were observed in these patients (Wilcoxon, p < 0.05), with a significant positive correlation between the AI values derived from PET and ASL (Pearson's correlation, r = 0.74, p < 0.05). Significance: In our SEEG- and outcome-defined patients with MTLE, ASL could provide significant information during presurgical evaluation, with the hypoperfusion detected with ASL reliably lateralizing MTLE. This non-invasive technique may be used as an alternative diagnostic tool for MTLE lateralization. Keywords: Arterial spin labeling (ASL), 18F-FDG PET, PET/MR, SEEG, Epilepsy |
| first_indexed | 2024-12-21T07:48:10Z |
| format | Article |
| id | doaj.art-a9c7f279344044079303d394e5c92c3c |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-21T07:48:10Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-a9c7f279344044079303d394e5c92c3c2022-12-21T19:11:09ZengElsevierNeuroImage: Clinical2213-15822018-01-0119824830Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEGYi-He Wang0Yang An1Xiao-Tong Fan2Jie Lu3Lian-Kun Ren4Peng-Hu Wei5Bi-Xiao Cui6Jia-Lin Du7Chao Lu8Di Wang9Hua-Qiang Zhang10Yong-Zhi Shan11Guo-Guang Zhao12Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Corresponding authors at: Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, No. 45, Changchun Street, Xuanwu District, Beijing 100053, China.Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing 100069, China; Corresponding authors at: Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, No. 45, Changchun Street, Xuanwu District, Beijing 100053, China.Objective: In the detection of seizure onset zones, arterial spin labeling (ASL) can overcome the limitations of positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG), which is invasive, expensive, and radioactive. PET/magnetic resonance (MR) systems have been introduced that allow simultaneous performance of ASL and PET, but comparisons of these techniques with stereoelectroencephalography (SEEG) and comparisons among the treatment outcomes of these techniques are still lacking. Here, we investigate the effectiveness of ASL compared with that of SEEG and their outcomes in localizing mesial temporal lobe epilepsy (MTLE) and assess the correlation between simultaneously acquired PET and ASL. Methods: Between October 2016 and August 2017, we retrospectively studied 12 patients diagnosed with pure unilateral MTLE. We extracted and quantitatively computed values for ASL and PET in the bilateral hippocampus. SEEG findings and outcome were considered the gold standard of lateralization. Finally, the bilateral asymmetry index (AI) was calculated to assess the correlation between PET and ASL. Results: Our results showed that hypoperfusion in the hippocampus detected using ASL matched the SEEG-defined epileptogenic zone in this series of patients. The mean normalized voxel value of ASL in the contralateral hippocampus was 0.97 ± 0.19, while in the ipsilateral hippocampus, it was 0.84 ± 0.14. Meanwhile, significantly decreased perfusion and metabolism were observed in these patients (Wilcoxon, p < 0.05), with a significant positive correlation between the AI values derived from PET and ASL (Pearson's correlation, r = 0.74, p < 0.05). Significance: In our SEEG- and outcome-defined patients with MTLE, ASL could provide significant information during presurgical evaluation, with the hypoperfusion detected with ASL reliably lateralizing MTLE. This non-invasive technique may be used as an alternative diagnostic tool for MTLE lateralization. Keywords: Arterial spin labeling (ASL), 18F-FDG PET, PET/MR, SEEG, Epilepsyhttp://www.sciencedirect.com/science/article/pii/S2213158218301918 |
| spellingShingle | Yi-He Wang Yang An Xiao-Tong Fan Jie Lu Lian-Kun Ren Peng-Hu Wei Bi-Xiao Cui Jia-Lin Du Chao Lu Di Wang Hua-Qiang Zhang Yong-Zhi Shan Guo-Guang Zhao Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG NeuroImage: Clinical |
| title | Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG |
| title_full | Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG |
| title_fullStr | Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG |
| title_full_unstemmed | Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG |
| title_short | Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG |
| title_sort | comparison between simultaneously acquired arterial spin labeling and 18f fdg pet in mesial temporal lobe epilepsy assisted by a pet mr system and seeg |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301918 |
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