Binding of sulphonylureas to plasma proteins - A KATP channel perspective.
Sulphonylurea drugs stimulate insulin secretion from pancreatic β-cells primarily by inhibiting ATP sensitive potassium (KATP) channels in the β-cell membrane. The effective sulphonylurea concentration at its site of action is significantly attenuated by binding to serum albumin, which makes it diff...
| Príomhchruthaitheoirí: | , , , |
|---|---|
| Formáid: | Alt |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
Public Library of Science (PLoS)
2018-01-01
|
| Sraith: | PLoS ONE |
| Rochtain ar líne: | http://europepmc.org/articles/PMC5957440?pdf=render |