A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial

A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial

IntroductionDespite advances in immunomodulatory treatments of multiple sclerosis (MS), patients with non-active progressive multiple sclerosis (PMS) continue to face a significant unmet need. Demyelination, smoldering inflammation and neurodegeneration are important drivers of disability progressio...

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Bibliographic Details
Main Authors: Anna-Victoria De Keersmaecker, Eline Van Doninck, Veronica Popescu, Lander Willem, Melissa Cambron, Guy Laureys, Miguel D’ Haeseleer, Maria Bjerke, Ella Roelant, Marc Lemmerling, Marie Beatrice D’hooghe, Judith Derdelinckx, Tatjana Reynders, Barbara Willekens
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
progressive multiple sclerosis
metformin
remyelination
neurodegeneration
neuroprotection
clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362629/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362629/full

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