The interplay between innate lymphoid cells and microbiota
ABSTRACT Innate lymphoid cells (ILCs) are mainly resident in mucosal tissues such as gastrointestinal tract and respiratory tract, so they are closely linked to the microbiota. ILCs can protect commensals to maintain homeostasis and increase resistance to pathogens. Moreover, ILCs also play an early...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2023-08-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mbio.00399-23 |
| _version_ | 1797730273717125120 |
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| author | Rui Wang Wenwen Cui Huan Yang |
| author_facet | Rui Wang Wenwen Cui Huan Yang |
| author_sort | Rui Wang |
| collection | DOAJ |
| description | ABSTRACT Innate lymphoid cells (ILCs) are mainly resident in mucosal tissues such as gastrointestinal tract and respiratory tract, so they are closely linked to the microbiota. ILCs can protect commensals to maintain homeostasis and increase resistance to pathogens. Moreover, ILCs also play an early role in defense against a variety of pathogenic microorganisms including pathogenic bacteria, viruses, fungi and parasites, before the intervention of adaptive immune system. Due to the lack of adaptive antigen receptors expressed on T cells and B cells, ILCs need to use other means to sense the signals of microbiota and play a role in corresponding regulation. In this review, we focus on and summarize three major mechanisms used in the interaction between ILCs and microbiota: the mediation of accessory cells represented by dendritic cells; the metabolic pathways of microbiota or diet; the participation of adaptive immune cells. |
| first_indexed | 2024-03-12T11:41:54Z |
| format | Article |
| id | doaj.art-a9cc4e2ff72a4e868c4e56f9bf819342 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-03-12T11:41:54Z |
| publishDate | 2023-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-a9cc4e2ff72a4e868c4e56f9bf8193422023-08-31T15:04:20ZengAmerican Society for MicrobiologymBio2150-75112023-08-0114410.1128/mbio.00399-23The interplay between innate lymphoid cells and microbiotaRui Wang0Wenwen Cui1Huan Yang2Xuzhou Key Laboratory of Laboratory Diagnostics, School of Medical Technology, Xuzhou Medical University , Xuzhou, ChinaXuzhou Key Laboratory of Laboratory Diagnostics, School of Medical Technology, Xuzhou Medical University , Xuzhou, ChinaXuzhou Key Laboratory of Laboratory Diagnostics, School of Medical Technology, Xuzhou Medical University , Xuzhou, ChinaABSTRACT Innate lymphoid cells (ILCs) are mainly resident in mucosal tissues such as gastrointestinal tract and respiratory tract, so they are closely linked to the microbiota. ILCs can protect commensals to maintain homeostasis and increase resistance to pathogens. Moreover, ILCs also play an early role in defense against a variety of pathogenic microorganisms including pathogenic bacteria, viruses, fungi and parasites, before the intervention of adaptive immune system. Due to the lack of adaptive antigen receptors expressed on T cells and B cells, ILCs need to use other means to sense the signals of microbiota and play a role in corresponding regulation. In this review, we focus on and summarize three major mechanisms used in the interaction between ILCs and microbiota: the mediation of accessory cells represented by dendritic cells; the metabolic pathways of microbiota or diet; the participation of adaptive immune cells.https://journals.asm.org/doi/10.1128/mbio.00399-23ILCmicrobiotaadaptive immuneDCmetabolite |
| spellingShingle | Rui Wang Wenwen Cui Huan Yang The interplay between innate lymphoid cells and microbiota mBio ILC microbiota adaptive immune DC metabolite |
| title | The interplay between innate lymphoid cells and microbiota |
| title_full | The interplay between innate lymphoid cells and microbiota |
| title_fullStr | The interplay between innate lymphoid cells and microbiota |
| title_full_unstemmed | The interplay between innate lymphoid cells and microbiota |
| title_short | The interplay between innate lymphoid cells and microbiota |
| title_sort | interplay between innate lymphoid cells and microbiota |
| topic | ILC microbiota adaptive immune DC metabolite |
| url | https://journals.asm.org/doi/10.1128/mbio.00399-23 |
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