JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression

JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression

Acetaminophen (APAP) is an analgesic–antipyretic drug and widely used in clinics. Its overdose may cause serious liver damage. Here, we examined the mechanistic role of c-Jun N-terminal kinase (JNK) signaling pathway in liver injury induced by different doses of APAP. Male mice were treated with APA...

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Bibliographic Details
Main Authors: Chenxi Shi, Beili Hao, Yang Yang, Ishfaq Muhammad, Yuanyuan Zhang, Yicong Chang, Ying Li, Changwen Li, Rui Li, Fangping Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
glutathione S-transferases A1
acetaminophen
c-Jun N-terminal kinase
liver injury
hepatotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01092/full

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