Microenvironment-derived factors driving metastatic plasticity in melanoma
Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the micr...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14343 |
| _version_ | 1818990650063847424 |
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| author | Isabella S. Kim Silja Heilmann Emily R. Kansler Yan Zhang Milena Zimmer Kajan Ratnakumar Robert L. Bowman Theresa Simon-Vermot Myles Fennell Ralph Garippa Liang Lu William Lee Travis Hollmann Joao B. Xavier Richard M. White |
| author_facet | Isabella S. Kim Silja Heilmann Emily R. Kansler Yan Zhang Milena Zimmer Kajan Ratnakumar Robert L. Bowman Theresa Simon-Vermot Myles Fennell Ralph Garippa Liang Lu William Lee Travis Hollmann Joao B. Xavier Richard M. White |
| author_sort | Isabella S. Kim |
| collection | DOAJ |
| description | Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the microenvironment. |
| first_indexed | 2024-12-20T19:57:44Z |
| format | Article |
| id | doaj.art-a9ccb537f389465d997a19a77c63d6c9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T19:57:44Z |
| publishDate | 2017-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a9ccb537f389465d997a19a77c63d6c92022-12-21T19:28:07ZengNature PortfolioNature Communications2041-17232017-02-018111110.1038/ncomms14343Microenvironment-derived factors driving metastatic plasticity in melanomaIsabella S. Kim0Silja Heilmann1Emily R. Kansler2Yan Zhang3Milena Zimmer4Kajan Ratnakumar5Robert L. Bowman6Theresa Simon-Vermot7Myles Fennell8Ralph Garippa9Liang Lu10William Lee11Travis Hollmann12Joao B. Xavier13Richard M. White14Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Computational Biology, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterMedical College of GeorgiaDepartment of Computational Biology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Computational Biology, Memorial Sloan Kettering Cancer CenterDepartment of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer CenterPhenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the microenvironment.https://doi.org/10.1038/ncomms14343 |
| spellingShingle | Isabella S. Kim Silja Heilmann Emily R. Kansler Yan Zhang Milena Zimmer Kajan Ratnakumar Robert L. Bowman Theresa Simon-Vermot Myles Fennell Ralph Garippa Liang Lu William Lee Travis Hollmann Joao B. Xavier Richard M. White Microenvironment-derived factors driving metastatic plasticity in melanoma Nature Communications |
| title | Microenvironment-derived factors driving metastatic plasticity in melanoma |
| title_full | Microenvironment-derived factors driving metastatic plasticity in melanoma |
| title_fullStr | Microenvironment-derived factors driving metastatic plasticity in melanoma |
| title_full_unstemmed | Microenvironment-derived factors driving metastatic plasticity in melanoma |
| title_short | Microenvironment-derived factors driving metastatic plasticity in melanoma |
| title_sort | microenvironment derived factors driving metastatic plasticity in melanoma |
| url | https://doi.org/10.1038/ncomms14343 |
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