Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

<p>Abstract</p> <p>Background</p> <p>Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA). Efficient phosphorylation requires that PKA be anchored close to its targets by A-kinase a...

Full description

Bibliographic Details
Main Authors:	Riedemann Johann, Mouton Jomien, Korkie Lundi J, Kinnear Craig J, Loos Benjamin, Ramburan Amsha, Uys Gerrida M, Moolman-Smook Johanna C
Format:	Article
Language:	English
Published:	BMC 2011-05-01
Series:	BMC Cell Biology
Online Access:	http://www.biomedcentral.com/1471-2121/12/18

Similar Items

Cardiac myosin binding protein C, adrenergic stimulation and cardiac contractility
by: Amsha Ramburan, et al.
Published: (2017-04-01)

Support for a trimeric collar of myosin binding protein C in cardiac and fast, but not slow, skeletal muscle
by: Moolman-Smook, J, et al.
Published: (2007)

Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle.
by: Flashman, E, et al.
Published: (2008)

Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C.
by: Moolman-Smook, J, et al.
Published: (2001)

Cardiac myosin binding protein C: its role in physiology and disease.
by: Flashman, E, et al.
Published: (2004)

Myomegalin is necessary for the formation of centrosomal and Golgi-derived microtubules
by: Régine Roubin, et al.
Published: (2012-12-01)

A novel interaction between the C5 and C8 domains of myosin binding protein-C and its modulation by HCM mutations
by: Flashman, E, et al.
Published: (2002)

Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations.
by: Moolman-Smook, J, et al.
Published: (2002)

Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins.
by: Dushek, O, et al.
Published: (2011)

Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction
by: Paola C. Rosas, MD, PhD, BSPharm, et al.
Published: (2019-11-01)

Alterations in Multi‐Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein‐C
by: Erik N. Taylor, et al.
Published: (2016-03-01)

Cardiac myosin binding protein-C phosphorylation modulates myofilament length-dependent activation
by: Ranganath eMamidi, et al.
Published: (2016-02-01)

Mutations of the light meromyosin domain of the beta-myosin heavy chain rod in hypertrophic cardiomyopathy.
by: Blair, E, et al.
Published: (2002)

TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
by: Alessandro Pietro Aldera, et al.
Published: (2022-05-01)

The growth hormone inducible transmembrane gene is a novel genetic modifier of left ventricular hypertrophy in families with hypertrophic cardiomyopathy
by: Parker, M, et al.
Published: (2009)

Phosphorylated Peptide Derived from the Myosin Phosphatase Target Subunit Is a Novel Inhibitor of Protein Phosphatase-1
by: Zoltán Kónya, et al.
Published: (2023-03-01)

Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins.
by: Markus S Schröder, et al.
Published: (2013-01-01)

Tools and protocol for quantification of myosin phosphorylation with MRM-MS
by: Justin A. MacDonald, et al.
Published: (2018-01-01)

Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells.
by: Jing-Ti Deng, et al.
Published: (2019-01-01)

Critical role of Rho proteins in myosin light chain di-phosphorylation during early phase of endothelial barrier disruption
by: Mayumi Hirano, et al.
Published: (2022-12-01)

Nonmuscle myosin IIA dynamically guides regulatory light chain phosphorylation and assembly of nonmuscle myosin IIB
by: Kai Weißenbruch, et al.
Published: (2022-04-01)

Cytokeratin expression in gastrointestinal stromal tumors: Morphology, meaning, and mimicry
by: Yetish Sing, et al.
Published: (2014-01-01)

Protein phosphorylation : analysis of protein phosphorylation, protein kinases inhibirors and protein phossphatases/
by: Hunter, Tony, et al.
Published: (1991)

Dynamic regulation of myosin light chain phosphorylation by Rho-kinase.
by: Takako Kaneko-Kawano, et al.
Published: (2012-01-01)

The Interplay between S-Glutathionylation and Phosphorylation of Cardiac Troponin I and Myosin Binding Protein C in End-Stage Human Failing Hearts
by: Heidi Budde, et al.
Published: (2021-07-01)

Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis
by: O’neal Copeland, et al.
Published: (2020-03-01)

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads
by: Anthony L. Hessel, et al.
Published: (2024-03-01)

Contiguity and Structural Impacts of a Non-Myosin Protein within the Thick Filament Myosin Layers
by: Lynda M. Menard, et al.
Published: (2021-07-01)

Anchored design of protein-protein interfaces.
by: Steven M Lewis, et al.
Published: (2011-01-01)

Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod.
by: Flashman, E, et al.
Published: (2007)

Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives
by: Yu, Haiyang, et al.
Published: (2016)

Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells.
by: Hui-Jun Yu, et al.
Published: (2013-01-01)

A role for myosin VI in the localization of axonal proteins.
by: Tommy L Lewis, et al.
Published: (2011-03-01)

Identification of a new mechanism for targeting myosin II heavy chain phosphorylation by <it>Dictyostelium </it>myosin heavy chain kinase B
by: Steimle Paul A, et al.
Published: (2010-03-01)

Data on whole length myosin binding protein C stabilizes myosin S2 as measured by gravitational force spectroscopy
by: Rohit R. Singh, et al.
Published: (2018-06-01)

New Isoform of Cardiac Myosin Light Chain Kinase and the Role of Cardiac Myosin Phosphorylation in α1-Adrenoceptor Mediated Inotropic Response.
by: Masaya Taniguchi, et al.
Published: (2015-01-01)

TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium
by: Karen Baker, et al.
Published: (2019-09-01)

Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization
by: Mihkel Örd, et al.
Published: (2020-06-01)

Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway.
by: Kenji Takemoto, et al.
Published: (2015-01-01)

Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models
by: Komal Ramani, et al.
Published: (2022-10-01)