Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus
Auras (focal aware seizure; FAS) are subjective ictal events with retained consciousness. Epileptiform activities can disrupt cognitive tasks, but studies are limited to seizures with impaired awareness. As a proof of concept, we examined the cognitive effects of direct electrical stimulation to the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | Epilepsy and Behavior Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213323218300860 |
| _version_ | 1818521337765822464 |
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| author | Diana Pizarro Emilia Toth Auriana Irannejad Kristen O. Riley Zeenat Jaisani Wolfgang Muhlhofer Roy Martin Sandipan Pati |
| author_facet | Diana Pizarro Emilia Toth Auriana Irannejad Kristen O. Riley Zeenat Jaisani Wolfgang Muhlhofer Roy Martin Sandipan Pati |
| author_sort | Diana Pizarro |
| collection | DOAJ |
| description | Auras (focal aware seizure; FAS) are subjective ictal events with retained consciousness. Epileptiform activities can disrupt cognitive tasks, but studies are limited to seizures with impaired awareness. As a proof of concept, we examined the cognitive effects of direct electrical stimulation to the left hippocampus which induced a habitual FAS in a patient with left mesial temporal lobe epilepsy. During the induced habitual FAS, verbal memory performance declined significantly as compared to pre-stimulation testing. Tasks measuring auditory working memory and psychomotor processing speed were not affected by the stimulation. The study confirms that FAS can impair episodic verbal memory and learning. Keywords: Verbal memory, Aura, Focal aware seizure, Learning, Hippocampus, Epilepsy |
| first_indexed | 2024-12-11T01:49:41Z |
| format | Article |
| id | doaj.art-a9cda61d224c44bf9baa620faf3c3905 |
| institution | Directory Open Access Journal |
| issn | 2213-3232 |
| language | English |
| last_indexed | 2024-12-11T01:49:41Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy and Behavior Case Reports |
| spelling | doaj.art-a9cda61d224c44bf9baa620faf3c39052022-12-22T01:24:47ZengElsevierEpilepsy and Behavior Case Reports2213-32322018-01-011099101Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampusDiana Pizarro0Emilia Toth1Auriana Irannejad2Kristen O. Riley3Zeenat Jaisani4Wolfgang Muhlhofer5Roy Martin6Sandipan Pati7Department of Neurology, University of Alabama at Birmingham, AL, United States of America; Epilepsy and Cognitive Neurophysiology Laboratory, University of Alabama at Birmingham, AL, United States of AmericaDepartment of Neurology, University of Alabama at Birmingham, AL, United States of America; Epilepsy and Cognitive Neurophysiology Laboratory, University of Alabama at Birmingham, AL, United States of AmericaEpilepsy and Cognitive Neurophysiology Laboratory, University of Alabama at Birmingham, AL, United States of AmericaDepartment of Neurosurgery, University of Alabama at Birmingham, AL, United States of AmericaDepartment of Neurology, University of Alabama at Birmingham, AL, United States of AmericaDepartment of Neurology, University of Alabama at Birmingham, AL, United States of AmericaDepartment of Neurology, University of Alabama at Birmingham, AL, United States of AmericaDepartment of Neurology, University of Alabama at Birmingham, AL, United States of America; Epilepsy and Cognitive Neurophysiology Laboratory, University of Alabama at Birmingham, AL, United States of America; Corresponding author at: Epilepsy and Cognitive Neurophysiology Laboratory, Department of Neurology, University of Alabama at Birmingham, CIRC 312, 1719 6th Avenue South, Birmingham, AL 35294, United States of America.Auras (focal aware seizure; FAS) are subjective ictal events with retained consciousness. Epileptiform activities can disrupt cognitive tasks, but studies are limited to seizures with impaired awareness. As a proof of concept, we examined the cognitive effects of direct electrical stimulation to the left hippocampus which induced a habitual FAS in a patient with left mesial temporal lobe epilepsy. During the induced habitual FAS, verbal memory performance declined significantly as compared to pre-stimulation testing. Tasks measuring auditory working memory and psychomotor processing speed were not affected by the stimulation. The study confirms that FAS can impair episodic verbal memory and learning. Keywords: Verbal memory, Aura, Focal aware seizure, Learning, Hippocampus, Epilepsyhttp://www.sciencedirect.com/science/article/pii/S2213323218300860 |
| spellingShingle | Diana Pizarro Emilia Toth Auriana Irannejad Kristen O. Riley Zeenat Jaisani Wolfgang Muhlhofer Roy Martin Sandipan Pati Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus Epilepsy and Behavior Case Reports |
| title | Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus |
| title_full | Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus |
| title_fullStr | Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus |
| title_full_unstemmed | Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus |
| title_short | Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus |
| title_sort | auras localized to the temporal lobe disrupt verbal memory and learning causal evidence from direct electrical stimulation of the hippocampus |
| url | http://www.sciencedirect.com/science/article/pii/S2213323218300860 |
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