Protein A Modulates Neutrophil and Keratinocyte Signaling and Survival in Response to Staphylococcus aureus

Protein A Modulates Neutrophil and Keratinocyte Signaling and Survival in Response to Staphylococcus aureus

The type 1 TNF-α receptor (TNFR1) has a central role in initiating both pro-inflammatory and pro-apoptotic signaling cascades in neutrophils. Considering that TNFR1 signals Staphylococcus aureus protein A (SpA), the aim of this study was to explore the interaction of this bacterial surface protein w...

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Bibliographic Details
Main Authors: Camila Ledo, Cintia D. Gonzalez, Ailin Garofalo, Florencia Sabbione, Irene A. Keitelman, Constanza Giai, Inés Stella, Analía S. Trevani, Marisa I. Gómez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
Staphylococcus aureus
protein A
neutrophils
type 1 TNF-α receptor
cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.524180/full

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