The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes
As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic sub...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2015-10-01
|
| Series: | Chimica Techno Acta |
| Subjects: | |
| Online Access: | https://journals.urfu.ru/index.php/chimtech/article/view/1281 |
| _version_ | 1819093759065849856 |
|---|---|
| author | N. R. Medvedeva I. S. Sapozhnikova V. L. Rusinov E. N. Ulomsky |
| author_facet | N. R. Medvedeva I. S. Sapozhnikova V. L. Rusinov E. N. Ulomsky |
| author_sort | N. R. Medvedeva |
| collection | DOAJ |
| description | As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic substitution sulfonyloxy group of cysteine and cysteamine with the formation of compounds 5 and 6. |
| first_indexed | 2024-12-21T23:16:37Z |
| format | Article |
| id | doaj.art-a9cfb1a28b6b4d059155539c615e3f15 |
| institution | Directory Open Access Journal |
| issn | 2409-5613 2411-1414 |
| language | English |
| last_indexed | 2024-12-21T23:16:37Z |
| publishDate | 2015-10-01 |
| publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj.art-a9cfb1a28b6b4d059155539c615e3f152022-12-21T18:46:55ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2409-56132411-14142015-10-012323424610.15826/chimtech.2015.2.3.0251520The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processesN. R. Medvedeva0I. S. Sapozhnikova1V. L. Rusinov2E. N. Ulomsky3Ural Federal University, EkaterinburgUral Federal University, EkaterinburgInstitute of Organic Synthesis UB RAS, Ural Federal University, EkaterinburgUral Federal University, EkaterinburgAs a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic substitution sulfonyloxy group of cysteine and cysteamine with the formation of compounds 5 and 6.https://journals.urfu.ru/index.php/chimtech/article/view/1281биологически активные соединениягетероциклытриазаверинантивирусные препараты |
| spellingShingle | N. R. Medvedeva I. S. Sapozhnikova V. L. Rusinov E. N. Ulomsky The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes Chimica Techno Acta биологически активные соединения гетероциклы триазаверин антивирусные препараты |
| title | The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes |
| title_full | The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes |
| title_fullStr | The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes |
| title_full_unstemmed | The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes |
| title_short | The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes |
| title_sort | redox transformations and nucleophilic replacements as possible metabolic reactions of the drug triazaverin the chemical modeling of the metabolic processes |
| topic | биологически активные соединения гетероциклы триазаверин антивирусные препараты |
| url | https://journals.urfu.ru/index.php/chimtech/article/view/1281 |
| work_keys_str_mv | AT nrmedvedeva theredoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses AT issapozhnikova theredoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses AT vlrusinov theredoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses AT enulomsky theredoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses AT nrmedvedeva redoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses AT issapozhnikova redoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses AT vlrusinov redoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses AT enulomsky redoxtransformationsandnucleophilicreplacementsaspossiblemetabolicreactionsofthedrugtriazaverinthechemicalmodelingofthemetabolicprocesses |