Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb Surgery
Background: Studies have reported lower pain threshold, spinal anesthesia duration, and level of sensoryblock in addicts compared to non-addict patients undergoing spinal anesthesia for surgery. Moreover, bloodgas and cerebrospinal fluid (CSF) were likely to be affected as well. The aim in the prese...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2020-01-01
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| Series: | Addiction and Health |
| Subjects: | |
| Online Access: | https://ahj.kmu.ac.ir/article_89586_25cb97a8ca736f49a67986b30fa7338f.pdf |
| _version_ | 1827825395232145408 |
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| author | Pooya Derakhshan Farnad Imani Seyed Alireza Seyed-Siamdoust Sorour Garousi Nasrin Nouri |
| author_facet | Pooya Derakhshan Farnad Imani Seyed Alireza Seyed-Siamdoust Sorour Garousi Nasrin Nouri |
| author_sort | Pooya Derakhshan |
| collection | DOAJ |
| description | Background: Studies have reported lower pain threshold, spinal anesthesia duration, and level of sensoryblock in addicts compared to non-addict patients undergoing spinal anesthesia for surgery. Moreover, bloodgas and cerebrospinal fluid (CSF) were likely to be affected as well. The aim in the present study is to evaluateCSF and spinal parameters in addict versus non-addict patients during lower limb surgery.Methods: In this case-control study, 22 opium addicts and 22 sex- and age- matched non-addicts undergoinglower limb surgery under spinal anesthesia were included. The CSF parameters, venous blood gas (VBG), andsensory and motor block findings were compared between the groups.Findings: The addict and non-addict patients were similar regarding CSF and blood gas parameters excepthigher pH in VBG (7.39 ± 0.06 vs. 7.33 ± 0.11, P = 0.030) and CSF (7.39 ± 0.06 vs. 7.33 ± 0.11, P = 0.030) foraddict patients. The addict patients had significantly later onset of sensory block (5.72 ± 1.57 vs. 3.16 ± 0.93minutes, P < 0.001) and shorter motor block duration (137.72 ± 11.51 vs. 149.09 ± 14.44 minutes, P = 0.006),with no significant difference in the sensory block duration and motor block onset.Conclusion: Addict patients have delayed onset of sensory block with shorter duration of motor block and lowersensory block level. Among the blood gas and CSF markers, only pH was significantly higher in addict patients,needing further evaluations; however, it seems that addiction has no significant effect on these parameters. |
| first_indexed | 2024-03-12T02:48:28Z |
| format | Article |
| id | doaj.art-a9d03dab200342e59bdd329550f1e140 |
| institution | Directory Open Access Journal |
| issn | 2008-4633 2008-8469 |
| language | English |
| last_indexed | 2024-03-12T02:48:28Z |
| publishDate | 2020-01-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Addiction and Health |
| spelling | doaj.art-a9d03dab200342e59bdd329550f1e1402023-09-04T06:17:41ZengKerman University of Medical SciencesAddiction and Health2008-46332008-84692020-01-01121111710.22122/ahj.v12i1.25789586Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb SurgeryPooya Derakhshan0Farnad Imani1Seyed Alireza Seyed-Siamdoust2Sorour Garousi3Nasrin Nouri4Pain Research Center, Iran University of Medical Sciences, Tehran, IranPain Research Center, Iran University of Medical Sciences, Tehran, IranPain Research Center, Iran University of Medical Sciences, Tehran, IranPain Research Center, Iran University of Medical Sciences, Tehran, IranPain Research Center, Iran University of Medical Sciences, Tehran, IranBackground: Studies have reported lower pain threshold, spinal anesthesia duration, and level of sensoryblock in addicts compared to non-addict patients undergoing spinal anesthesia for surgery. Moreover, bloodgas and cerebrospinal fluid (CSF) were likely to be affected as well. The aim in the present study is to evaluateCSF and spinal parameters in addict versus non-addict patients during lower limb surgery.Methods: In this case-control study, 22 opium addicts and 22 sex- and age- matched non-addicts undergoinglower limb surgery under spinal anesthesia were included. The CSF parameters, venous blood gas (VBG), andsensory and motor block findings were compared between the groups.Findings: The addict and non-addict patients were similar regarding CSF and blood gas parameters excepthigher pH in VBG (7.39 ± 0.06 vs. 7.33 ± 0.11, P = 0.030) and CSF (7.39 ± 0.06 vs. 7.33 ± 0.11, P = 0.030) foraddict patients. The addict patients had significantly later onset of sensory block (5.72 ± 1.57 vs. 3.16 ± 0.93minutes, P < 0.001) and shorter motor block duration (137.72 ± 11.51 vs. 149.09 ± 14.44 minutes, P = 0.006),with no significant difference in the sensory block duration and motor block onset.Conclusion: Addict patients have delayed onset of sensory block with shorter duration of motor block and lowersensory block level. Among the blood gas and CSF markers, only pH was significantly higher in addict patients,needing further evaluations; however, it seems that addiction has no significant effect on these parameters.https://ahj.kmu.ac.ir/article_89586_25cb97a8ca736f49a67986b30fa7338f.pdfopioid-related disordersanesthesia, spinalopiumbupivacainecerebrospinal fluid |
| spellingShingle | Pooya Derakhshan Farnad Imani Seyed Alireza Seyed-Siamdoust Sorour Garousi Nasrin Nouri Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb Surgery Addiction and Health opioid-related disorders anesthesia, spinal opium bupivacaine cerebrospinal fluid |
| title | Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb Surgery |
| title_full | Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb Surgery |
| title_fullStr | Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb Surgery |
| title_full_unstemmed | Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb Surgery |
| title_short | Cerebrospinal Fluid and Spinal Anesthesia Parameters in Healthy Versus Opium-Addict Patients during Lower Limb Surgery |
| title_sort | cerebrospinal fluid and spinal anesthesia parameters in healthy versus opium addict patients during lower limb surgery |
| topic | opioid-related disorders anesthesia, spinal opium bupivacaine cerebrospinal fluid |
| url | https://ahj.kmu.ac.ir/article_89586_25cb97a8ca736f49a67986b30fa7338f.pdf |
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