Biomimetic Approaches in Clinical Endodontics
In the last few decades, biomimetic concepts have been widely adopted in various biomedical fields, including clinical dentistry. Endodontics is an important sub-branch of dentistry which deals with the different conditions of pulp to prevent tooth loss. Traditionally, common procedures, namely pulp...
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MDPI AG
2022-12-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/7/4/229 |
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| author | Naresh Kumar Nazrah Maher Faiza Amin Hani Ghabbani Muhammad Sohail Zafar Francisco Javier Rodríguez-Lozano Ricardo E. Oñate-Sánchez |
| author_facet | Naresh Kumar Nazrah Maher Faiza Amin Hani Ghabbani Muhammad Sohail Zafar Francisco Javier Rodríguez-Lozano Ricardo E. Oñate-Sánchez |
| author_sort | Naresh Kumar |
| collection | DOAJ |
| description | In the last few decades, biomimetic concepts have been widely adopted in various biomedical fields, including clinical dentistry. Endodontics is an important sub-branch of dentistry which deals with the different conditions of pulp to prevent tooth loss. Traditionally, common procedures, namely pulp capping, root canal treatment, apexification, and apexigonesis, have been considered for the treatment of different pulp conditions using selected materials. However, clinically to regenerate dental pulp, tissue engineering has been advocated as a feasible approach. Currently, new trends are emerging in terms of regenerative endodontics which have led to the replacement of diseased and non-vital teeth into the functional and healthy dentine-pulp complex. Root- canal therapy is the standard management option when dental pulp is damaged irreversibly. This treatment modality involves soft-tissue removal and then filling that gap through the obturation technique with a synthetic material. The formation of tubular dentine and pulp-like tissue formation occurs when stem cells are transplanted into the root canal with an appropriate scaffold material. To sum up tissue engineering approach includes three components: (1) scaffold, (2) differentiation, growth, and factors, and (3) the recruitment of stem cells within the pulp or from the periapical region. The aim of this paper is to thoroughly review and discuss various pulp-regenerative approaches and materials used in regenerative endodontics which may highlight the current trends and future research prospects in this particular area. |
| first_indexed | 2024-03-09T17:17:32Z |
| format | Article |
| id | doaj.art-a9d044e13d4b4b4fbb882990b1d51957 |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-03-09T17:17:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-a9d044e13d4b4b4fbb882990b1d519572023-11-24T13:31:50ZengMDPI AGBiomimetics2313-76732022-12-017422910.3390/biomimetics7040229Biomimetic Approaches in Clinical EndodonticsNaresh Kumar0Nazrah Maher1Faiza Amin2Hani Ghabbani3Muhammad Sohail Zafar4Francisco Javier Rodríguez-Lozano5Ricardo E. Oñate-Sánchez6Department of Science of Dental Materials, Dr. Ishrat Ul Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi 74200, PakistanDepartment of Science of Dental Materials, Dr. Ishrat Ul Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi 74200, PakistanDepartment of Science of Dental Materials, Dow Dental College, Dow University of Health Sciences, Karachi 74200, PakistanDepartment of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah, Al Munawwarah 41311, Saudi ArabiaDepartment of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah, Al Munawwarah 41311, Saudi ArabiaDepartment of Special Care in Dentistry, Hospital Morales Meseguer, IMIB-Arrixaca, University of Murcia, 30008 Murcia, SpainDepartment of Special Care in Dentistry, Hospital Morales Meseguer, IMIB-Arrixaca, University of Murcia, 30008 Murcia, SpainIn the last few decades, biomimetic concepts have been widely adopted in various biomedical fields, including clinical dentistry. Endodontics is an important sub-branch of dentistry which deals with the different conditions of pulp to prevent tooth loss. Traditionally, common procedures, namely pulp capping, root canal treatment, apexification, and apexigonesis, have been considered for the treatment of different pulp conditions using selected materials. However, clinically to regenerate dental pulp, tissue engineering has been advocated as a feasible approach. Currently, new trends are emerging in terms of regenerative endodontics which have led to the replacement of diseased and non-vital teeth into the functional and healthy dentine-pulp complex. Root- canal therapy is the standard management option when dental pulp is damaged irreversibly. This treatment modality involves soft-tissue removal and then filling that gap through the obturation technique with a synthetic material. The formation of tubular dentine and pulp-like tissue formation occurs when stem cells are transplanted into the root canal with an appropriate scaffold material. To sum up tissue engineering approach includes three components: (1) scaffold, (2) differentiation, growth, and factors, and (3) the recruitment of stem cells within the pulp or from the periapical region. The aim of this paper is to thoroughly review and discuss various pulp-regenerative approaches and materials used in regenerative endodontics which may highlight the current trends and future research prospects in this particular area.https://www.mdpi.com/2313-7673/7/4/229endodontiaregenerative endodonticsrevascularizationrevitalization |
| spellingShingle | Naresh Kumar Nazrah Maher Faiza Amin Hani Ghabbani Muhammad Sohail Zafar Francisco Javier Rodríguez-Lozano Ricardo E. Oñate-Sánchez Biomimetic Approaches in Clinical Endodontics Biomimetics endodontia regenerative endodontics revascularization revitalization |
| title | Biomimetic Approaches in Clinical Endodontics |
| title_full | Biomimetic Approaches in Clinical Endodontics |
| title_fullStr | Biomimetic Approaches in Clinical Endodontics |
| title_full_unstemmed | Biomimetic Approaches in Clinical Endodontics |
| title_short | Biomimetic Approaches in Clinical Endodontics |
| title_sort | biomimetic approaches in clinical endodontics |
| topic | endodontia regenerative endodontics revascularization revitalization |
| url | https://www.mdpi.com/2313-7673/7/4/229 |
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