Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary
Short-bowel syndrome represents the most common cause of intestinal failure and occurs when the remaining intestine cannot support fluid and nutrient needs to sustain adequate physiology and development without the use of supplemental parenteral nutrition. After intestinal loss or damage, the remnan...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X18300341 |
| _version_ | 1819150370513879040 |
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| author | Justine Marchix Gillian Goddard Michael A. Helmrath |
| author_facet | Justine Marchix Gillian Goddard Michael A. Helmrath |
| author_sort | Justine Marchix |
| collection | DOAJ |
| description | Short-bowel syndrome represents the most common cause of intestinal failure and occurs when the remaining intestine cannot support fluid and nutrient needs to sustain adequate physiology and development without the use of supplemental parenteral nutrition. After intestinal loss or damage, the remnant bowel undergoes multifactorial compensatory processes, termed adaptation, which are largely driven by intraluminal nutrient exposure. Previous studies have provided insight into the biological processes and mediators after resection, however, there still remains a gap in the knowledge of more comprehensive mechanisms that drive the adaptive responses in these patients. Recent data support the microbiota as a key mediator of gut homeostasis and a potential driver of metabolism and immunomodulation after intestinal loss. In this review, we summarize the emerging ideas related to host-microbiota interactions in the intestinal adaptation processes. Keywords: Enteric Flora, Immune System, Intestinal Failure, Adaptive Responses, Microbial Metabolites |
| first_indexed | 2024-12-22T14:16:26Z |
| format | Article |
| id | doaj.art-a9d2bfde6a3d42d4a678ce5dc2edaed1 |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-12-22T14:16:26Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-a9d2bfde6a3d42d4a678ce5dc2edaed12022-12-21T18:23:06ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2018-01-0162149162Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummaryJustine Marchix0Gillian Goddard1Michael A. Helmrath2Division of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OhioDepartment of General Surgery, University of Cincinnati, Cincinnati, OhioDivision of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio; Department of General Surgery, University of Cincinnati, Cincinnati, Ohio; Correspondence Address correspondence to: Michael A. Helmrath, MD, Division of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3026. fax: (513) 636-7657.Short-bowel syndrome represents the most common cause of intestinal failure and occurs when the remaining intestine cannot support fluid and nutrient needs to sustain adequate physiology and development without the use of supplemental parenteral nutrition. After intestinal loss or damage, the remnant bowel undergoes multifactorial compensatory processes, termed adaptation, which are largely driven by intraluminal nutrient exposure. Previous studies have provided insight into the biological processes and mediators after resection, however, there still remains a gap in the knowledge of more comprehensive mechanisms that drive the adaptive responses in these patients. Recent data support the microbiota as a key mediator of gut homeostasis and a potential driver of metabolism and immunomodulation after intestinal loss. In this review, we summarize the emerging ideas related to host-microbiota interactions in the intestinal adaptation processes. Keywords: Enteric Flora, Immune System, Intestinal Failure, Adaptive Responses, Microbial Metaboliteshttp://www.sciencedirect.com/science/article/pii/S2352345X18300341 |
| spellingShingle | Justine Marchix Gillian Goddard Michael A. Helmrath Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary Cellular and Molecular Gastroenterology and Hepatology |
| title | Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary |
| title_full | Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary |
| title_fullStr | Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary |
| title_full_unstemmed | Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary |
| title_short | Host-Gut Microbiota Crosstalk in Intestinal AdaptationSummary |
| title_sort | host gut microbiota crosstalk in intestinal adaptationsummary |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X18300341 |
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