First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in Brazil
Abstract Background This study describes the effectiveness of a novel active pharmaceutical ingredient, fluralaner (isoxazoline class), against important ectoparasites infesting cattle in Brazil. Methods A total of 13 studies involving a 5% fluralaner-based pour-on formulation (Exzolt 5%; further re...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-023-05934-7 |
| _version_ | 1797577835311792128 |
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| author | Alvimar José da Costa João Ricardo de Souza Martins Fernando de Almeida Borges Luis Fernando Vettorato Francisco Bonomi Barufi Heitor de Oliveira Arriero Amaral Luara Carolina Abujamra Daniel de Castro Rodrigues Welber Daniel Zanetti Lopes |
| author_facet | Alvimar José da Costa João Ricardo de Souza Martins Fernando de Almeida Borges Luis Fernando Vettorato Francisco Bonomi Barufi Heitor de Oliveira Arriero Amaral Luara Carolina Abujamra Daniel de Castro Rodrigues Welber Daniel Zanetti Lopes |
| author_sort | Alvimar José da Costa |
| collection | DOAJ |
| description | Abstract Background This study describes the effectiveness of a novel active pharmaceutical ingredient, fluralaner (isoxazoline class), against important ectoparasites infesting cattle in Brazil. Methods A total of 13 studies involving a 5% fluralaner-based pour-on formulation (Exzolt 5%; further referred to as Exzolt) were conducted. Specifically, the effectiveness of this formulation was studied against Rhipicephalus microplus (6 studies), Cochliomyia hominivorax larvae (4 studies), Dermatobia hominis larvae (1 study) and Haematobia irritans flies (2 studies). Results The therapeutic efficacy of Exzolt was found to exceed 98% at 4 days post treatment (DPT), while persistent efficacy (> 90% efficacy) against repeated infestations of R. microplus was observed for up to 79 DPT. In field studies, ≥ 98% therapeutic efficacy was demonstrated at all study sites by 7 DPT, and a persistent efficacy (> 90% efficacy) was observed for 42, 49 or 56 DPT. Exzolt prevented C. hominivorax eggs from developing to the larval stage, thus mitigating the development of myiasis in cattle naturally and artificially infested with this screworm. The efficacy of Exzolt against D. hominis larvae was 98% at 3 DPT, while persistent efficacy (> 90% effectiveness) was found to last for up to 70 DPT. Against H. irritans, Exzolt showed therapeutic efficacy (≥ 90%) within the first day of treatment at both study sites, while persistent efficacy (≥ 90%) was observed for 7 DPT at one site and for 21 DPT at the other site. Conclusions Overall, the results from these studies confirm that Exzolt is therapeutically efficacious against the most important ectoparasites infesting cattle in Brazil. The novel active pharmaceutical ingredient, fluralaner, provides a new treatment option for farmers to control cattle ectoparasites, especially where there is resistance to other chemical classes. In addition, an effective control of ectoparasites will improve overall cattle health and well-being as well as production. Graphical Abstract |
| first_indexed | 2024-03-10T22:13:36Z |
| format | Article |
| id | doaj.art-a9d43a3109da4ff3833fceabd7ef79d7 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-03-10T22:13:36Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-a9d43a3109da4ff3833fceabd7ef79d72023-11-19T12:31:19ZengBMCParasites & Vectors1756-33052023-09-0116112010.1186/s13071-023-05934-7First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in BrazilAlvimar José da Costa0João Ricardo de Souza Martins1Fernando de Almeida Borges2Luis Fernando Vettorato3Francisco Bonomi Barufi4Heitor de Oliveira Arriero Amaral5Luara Carolina Abujamra6Daniel de Castro Rodrigues7Welber Daniel Zanetti Lopes8Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual PaulistaInstituto de Pesquisas Desidério FinamorDepartamento de Medicina Veterinária, Universidade Federal do Mato Grosso Do SulMSD Saúde AnimalMSD Saúde AnimalMSD Saúde AnimalMSD Saúde AnimalMSD Saúde AnimalCentro de Parasitologia Veterinária, Universidade Federal de GoiásAbstract Background This study describes the effectiveness of a novel active pharmaceutical ingredient, fluralaner (isoxazoline class), against important ectoparasites infesting cattle in Brazil. Methods A total of 13 studies involving a 5% fluralaner-based pour-on formulation (Exzolt 5%; further referred to as Exzolt) were conducted. Specifically, the effectiveness of this formulation was studied against Rhipicephalus microplus (6 studies), Cochliomyia hominivorax larvae (4 studies), Dermatobia hominis larvae (1 study) and Haematobia irritans flies (2 studies). Results The therapeutic efficacy of Exzolt was found to exceed 98% at 4 days post treatment (DPT), while persistent efficacy (> 90% efficacy) against repeated infestations of R. microplus was observed for up to 79 DPT. In field studies, ≥ 98% therapeutic efficacy was demonstrated at all study sites by 7 DPT, and a persistent efficacy (> 90% efficacy) was observed for 42, 49 or 56 DPT. Exzolt prevented C. hominivorax eggs from developing to the larval stage, thus mitigating the development of myiasis in cattle naturally and artificially infested with this screworm. The efficacy of Exzolt against D. hominis larvae was 98% at 3 DPT, while persistent efficacy (> 90% effectiveness) was found to last for up to 70 DPT. Against H. irritans, Exzolt showed therapeutic efficacy (≥ 90%) within the first day of treatment at both study sites, while persistent efficacy (≥ 90%) was observed for 7 DPT at one site and for 21 DPT at the other site. Conclusions Overall, the results from these studies confirm that Exzolt is therapeutically efficacious against the most important ectoparasites infesting cattle in Brazil. The novel active pharmaceutical ingredient, fluralaner, provides a new treatment option for farmers to control cattle ectoparasites, especially where there is resistance to other chemical classes. In addition, an effective control of ectoparasites will improve overall cattle health and well-being as well as production. Graphical Abstracthttps://doi.org/10.1186/s13071-023-05934-7Cochliomyia hominivoraxDermatobia hominisFluralanerHaematobia irritansIsoxazolineRhipicephalus microplus |
| spellingShingle | Alvimar José da Costa João Ricardo de Souza Martins Fernando de Almeida Borges Luis Fernando Vettorato Francisco Bonomi Barufi Heitor de Oliveira Arriero Amaral Luara Carolina Abujamra Daniel de Castro Rodrigues Welber Daniel Zanetti Lopes First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in Brazil Parasites & Vectors Cochliomyia hominivorax Dermatobia hominis Fluralaner Haematobia irritans Isoxazoline Rhipicephalus microplus |
| title | First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in Brazil |
| title_full | First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in Brazil |
| title_fullStr | First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in Brazil |
| title_full_unstemmed | First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in Brazil |
| title_short | First report of the efficacy of a fluralaner-based pour-on product (Exzolt® 5%) against ectoparasites infesting cattle in Brazil |
| title_sort | first report of the efficacy of a fluralaner based pour on product exzolt r 5 against ectoparasites infesting cattle in brazil |
| topic | Cochliomyia hominivorax Dermatobia hominis Fluralaner Haematobia irritans Isoxazoline Rhipicephalus microplus |
| url | https://doi.org/10.1186/s13071-023-05934-7 |
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