25 Years of PI5P
The accidental discovery of PI5P (phosphatidylinositol-5-phosphate) was published 25 years ago, when PIP5K type II (phosphoinositide-4-phosphate 5-kinase) was shown to actually be a 4-kinase that uses PI5P as a substrate to generate PI(4,5)P2. Consequently, PIP5K type II was renamed to PI5P4K, or PI...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1272911/full |
| _version_ | 1797668173813645312 |
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| author | Lucia E. Rameh Raymond D. Blind |
| author_facet | Lucia E. Rameh Raymond D. Blind |
| author_sort | Lucia E. Rameh |
| collection | DOAJ |
| description | The accidental discovery of PI5P (phosphatidylinositol-5-phosphate) was published 25 years ago, when PIP5K type II (phosphoinositide-4-phosphate 5-kinase) was shown to actually be a 4-kinase that uses PI5P as a substrate to generate PI(4,5)P2. Consequently, PIP5K type II was renamed to PI5P4K, or PIP4K for short, and PI5P became the last of the 7 signaling phosphoinositides to be discovered. Much of what we know about PI5P comes from genetic studies of PIP4K, as the pathways for PI5P synthesis, the downstream targets of PI5P and how PI5P affects cellular function all remain largely enigmatic. Nevertheless, PI5P and PI5P-dependent PI(4,5)P2 synthesis have been clearly implicated in metabolic homeostasis and in diseases such as cancer. Here, we review the past 25 years of PI5P research, with particular emphasis on the impact this small signaling lipid has on human health. |
| first_indexed | 2024-03-11T20:25:35Z |
| format | Article |
| id | doaj.art-a9d5526e4de24bb3ba0b53e30cd709ae |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T20:25:35Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a9d5526e4de24bb3ba0b53e30cd709ae2023-10-02T16:26:51ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-10-011110.3389/fcell.2023.1272911127291125 Years of PI5PLucia E. RamehRaymond D. BlindThe accidental discovery of PI5P (phosphatidylinositol-5-phosphate) was published 25 years ago, when PIP5K type II (phosphoinositide-4-phosphate 5-kinase) was shown to actually be a 4-kinase that uses PI5P as a substrate to generate PI(4,5)P2. Consequently, PIP5K type II was renamed to PI5P4K, or PIP4K for short, and PI5P became the last of the 7 signaling phosphoinositides to be discovered. Much of what we know about PI5P comes from genetic studies of PIP4K, as the pathways for PI5P synthesis, the downstream targets of PI5P and how PI5P affects cellular function all remain largely enigmatic. Nevertheless, PI5P and PI5P-dependent PI(4,5)P2 synthesis have been clearly implicated in metabolic homeostasis and in diseases such as cancer. Here, we review the past 25 years of PI5P research, with particular emphasis on the impact this small signaling lipid has on human health.https://www.frontiersin.org/articles/10.3389/fcell.2023.1272911/fullPI5PPIP4KPI(4,5)P2PIKfyveTMEMs |
| spellingShingle | Lucia E. Rameh Raymond D. Blind 25 Years of PI5P Frontiers in Cell and Developmental Biology PI5P PIP4K PI(4,5)P2 PIKfyve TMEMs |
| title | 25 Years of PI5P |
| title_full | 25 Years of PI5P |
| title_fullStr | 25 Years of PI5P |
| title_full_unstemmed | 25 Years of PI5P |
| title_short | 25 Years of PI5P |
| title_sort | 25 years of pi5p |
| topic | PI5P PIP4K PI(4,5)P2 PIKfyve TMEMs |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1272911/full |
| work_keys_str_mv | AT luciaerameh 25yearsofpi5p AT raymonddblind 25yearsofpi5p |