Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.

Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.

BACKGROUND: The vascular endothelium plays a critical role in the control of blood flow. Altered endothelium-mediated vasodilator and vasoconstrictor mechanisms underlie key aspects of cardiovascular disease, including those in obesity. Whilst the mechanism of nitric oxide (NO)-mediated vasodilation...

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Bibliographic Details
Main Authors: Rebecca E Haddock, T Hilton Grayson, Margaret J Morris, Lauren Howitt, Preet S Chadha, Shaun L Sandow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3025034?pdf=render

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