Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II

Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II

Paracrine interactions between malignant estrogen receptor positive (ER<sup>+</sup>) breast cancer cells and breast adipose fibroblasts (BAFs) stimulate estrogen biosynthesis by aromatase in BAFs. In breast cancer, mainly the cAMP-responsive promoter I.3/II-region mediates excessive arom...

Full description

Bibliographic Details
Main Authors:	Alexander Kaiser, Thomas Krüger, Gabriele Eiselt, Joachim Bechler, Olaf Kniemeyer, Otmar Huber, Martin Schmidt
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Cells
Subjects:	breast cancer estrogen synthesis breast adipose fibroblasts adipose stromal cells epigenetics sirt-1 parp-1
Online Access:	https://www.mdpi.com/2073-4409/9/2/427

Similar Items

WNT3a Signaling Inhibits Aromatase Expression in Breast Adipose Fibroblasts—A Possible Mechanism Supporting the Loss of Estrogen Responsiveness of Triple-Negative Breast Cancers
by: Alexander Kaiser, et al.
Published: (2023-02-01)

Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases
by: Hun Taeg Chung, et al.
Published: (2014-12-01)

Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury
by: Naijin Zhang, et al.
Published: (2021-11-01)

Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
by: Mar Quiñones, et al.
Published: (2021-01-01)

PARP-1 and SIRT-1 are Interacted in Diabetic Nephropathy by Activating AMPK/PGC-1α Signaling Pathway
by: Zhu H, et al.
Published: (2021-01-01)

Obesity exacerbates postoperative cognitive dysfunction by activating the PARP1/NAD+/SIRT1 axis through oxidative stress
by: Li Xu, et al.
Published: (2023-11-01)

Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
by: Khaldoun Rifaï, et al.
Published: (2018-10-01)

Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
by: Yun Shan, et al.
Published: (2020-12-01)

Seabuckthorn Reverses High-Fat-Diet-Induced Obesity and Enhances Fat Browning via Activation of AMPK/SIRT1 Pathway
by: Yu Wang, et al.
Published: (2022-07-01)

Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells
by: Nicholas Pulliam, et al.
Published: (2019-01-01)

Cdh1 Deficiency Sensitizes TNBC Cells to PARP Inhibitors
by: Junjun Li, et al.
Published: (2022-04-01)

Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice
by: Rossella Tozzi, et al.
Published: (2022-12-01)

SIRT1-mediated intermittent fasting improves adipose tissue mitochondrial function and inflammation in high-fat diet-induced obese mice
by: Deng Xiaojie, Wang Tian, Xu Fen, Liang Hua
Published: (2023-04-01)

Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights
by: Ashwin Ragupathi, et al.
Published: (2023-03-01)

PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
by: Natalya V. Maluchenko, et al.
Published: (2021-10-01)

Exogenous Nucleotides Improved the Oxidative Stress and Sirt-1 Protein Level of Brown Adipose Tissue on Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice
by: Xiujuan Wang, et al.
Published: (2022-07-01)

Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa
by: Stefania Mariani, et al.
Published: (2020-11-01)

Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis
by: Keke Wu, et al.
Published: (2023-01-01)

PARP-1 Expression and <i>BRCA1</i> Mutations in Breast Cancer Patients’ CTCs
by: Thodoris Sklias, et al.
Published: (2022-03-01)

BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study
by: Jolanta Hybiak, et al.
Published: (2019-01-01)

Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence?
by: Francesca Piccotti, et al.
Published: (2021-04-01)

Correlation between PARP-1 immunoreactivity and cytomorphological features of parthanatos, a specific cellular death in breast cancer cells
by: P. Donizy, et al.
Published: (2013-11-01)

FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer
by: Marisol Castillo-Castrejon, et al.
Published: (2023-08-01)

The Prognostic Values of PARP-1 Expression in Uveal Melanoma
by: Malgorzata Gajdzis, et al.
Published: (2021-01-01)

TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study
by: Serena Bertozzi, et al.
Published: (2021-10-01)

Transcriptional Regulation of <i>CCL2</i> by PARP1 Is a Driver for Invasiveness in Breast Cancer
by: Pranabananda Dutta, et al.
Published: (2020-05-01)

SIRT1/FOXO Signaling Pathway in Breast Cancer Progression and Metastasis
by: Sayra Dilmac, et al.
Published: (2022-09-01)

Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD
by: Trine Baur Opstad, et al.
Published: (2023-09-01)

HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway
by: Chenyue Ding, et al.
Published: (2018-02-01)

Silencing of PARP2 Blocks Autophagic Degradation
by: Laura Jankó, et al.
Published: (2020-02-01)

Combination Treatment Strategies to Overcome PARP Inhibitor Resistance
by: Young-Hwa Soung, et al.
Published: (2023-10-01)

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
by: John R. P. Knight, et al.
Published: (2013-01-01)

Circulating SIRT1 and Sclerostin Correlates with Bone Status in Young Women with Different Degrees of Adiposity
by: Rossella Tozzi, et al.
Published: (2022-02-01)

Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases
by: Fang Wang, et al.
Published: (2020-10-01)

OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
by: Juan Miguel Baquero, et al.
Published: (2022-05-01)

Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation
by: Xiaoxiong Huang, et al.
Published: (2023-01-01)

Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization
by: Yanzhong Wang, et al.
Published: (2019-05-01)

Moving beyond PARP Inhibition: Current State and Future Perspectives in Breast Cancer
by: Michela Palleschi, et al.
Published: (2021-07-01)

The Effect of Antiretroviral Therapy on SIRT1, SIRT3 and SIRT6 Expression in HIV-Infected Patients
by: Karolina Jurkowska, et al.
Published: (2022-02-01)

Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods
by: Hongye Hu, et al.
Published: (2020-05-01)