Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics
Antibiotic-producing organisms need to co-evolve self-protection mechanisms to avoid any damage to themselves caused by the antibiotic pharmacophore (the reactive part of the compound). In this study, the authors report a self-defense strategy in naphthyridinomycin (NDM)-producing Streptomyces lusit...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27404-3 |
| _version_ | 1818402357633875968 |
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| author | Wan-Hong Wen Yue Zhang Ying-Ying Zhang Qian Yu Chu-Chu Jiang Man-Cheng Tang Jin-Yue Pu Lian Wu Yi-Lei Zhao Ting Shi Jiahai Zhou Gong-Li Tang |
| author_facet | Wan-Hong Wen Yue Zhang Ying-Ying Zhang Qian Yu Chu-Chu Jiang Man-Cheng Tang Jin-Yue Pu Lian Wu Yi-Lei Zhao Ting Shi Jiahai Zhou Gong-Li Tang |
| author_sort | Wan-Hong Wen |
| collection | DOAJ |
| description | Antibiotic-producing organisms need to co-evolve self-protection mechanisms to avoid any damage to themselves caused by the antibiotic pharmacophore (the reactive part of the compound). In this study, the authors report a self-defense strategy in naphthyridinomycin (NDM)-producing Streptomyces lusitanus, that comprises reductive inactivation of the hemiaminal pharmacophore by short-chain dehydrogenases/reductases (SDRs) NapW and HomW. |
| first_indexed | 2024-12-14T08:07:05Z |
| format | Article |
| id | doaj.art-a9d68f79ffe343329d07e275519c194a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:07:05Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a9d68f79ffe343329d07e275519c194a2022-12-21T23:10:09ZengNature PortfolioNature Communications2041-17232021-12-0112111110.1038/s41467-021-27404-3Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibioticsWan-Hong Wen0Yue Zhang1Ying-Ying Zhang2Qian Yu3Chu-Chu Jiang4Man-Cheng Tang5Jin-Yue Pu6Lian Wu7Yi-Lei Zhao8Ting Shi9Jiahai Zhou10Gong-Li Tang11State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong UniversityState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong UniversityState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong UniversityState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong UniversityCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of SciencesState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesAntibiotic-producing organisms need to co-evolve self-protection mechanisms to avoid any damage to themselves caused by the antibiotic pharmacophore (the reactive part of the compound). In this study, the authors report a self-defense strategy in naphthyridinomycin (NDM)-producing Streptomyces lusitanus, that comprises reductive inactivation of the hemiaminal pharmacophore by short-chain dehydrogenases/reductases (SDRs) NapW and HomW.https://doi.org/10.1038/s41467-021-27404-3 |
| spellingShingle | Wan-Hong Wen Yue Zhang Ying-Ying Zhang Qian Yu Chu-Chu Jiang Man-Cheng Tang Jin-Yue Pu Lian Wu Yi-Lei Zhao Ting Shi Jiahai Zhou Gong-Li Tang Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics Nature Communications |
| title | Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics |
| title_full | Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics |
| title_fullStr | Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics |
| title_full_unstemmed | Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics |
| title_short | Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics |
| title_sort | reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics |
| url | https://doi.org/10.1038/s41467-021-27404-3 |
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