Shared functional connectome fingerprints following ritualistic ayahuasca intake
The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such “fingerprints” persist under altered states of consciousness is unknown. Ayahuasca is a potent serotonergic psychedelic which produces a wid...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923006304 |
| _version_ | 1827385804410847232 |
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| author | Pablo Mallaroni Natasha L. Mason Lilian Kloft Johannes T. Reckweg Kim van Oorsouw Stefan W. Toennes Hanna M. Tolle Enrico Amico Johannes G. Ramaekers |
| author_facet | Pablo Mallaroni Natasha L. Mason Lilian Kloft Johannes T. Reckweg Kim van Oorsouw Stefan W. Toennes Hanna M. Tolle Enrico Amico Johannes G. Ramaekers |
| author_sort | Pablo Mallaroni |
| collection | DOAJ |
| description | The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such “fingerprints” persist under altered states of consciousness is unknown. Ayahuasca is a potent serotonergic psychedelic which produces a widespread dysregulation of functional connectivity. Used communally in religious ceremonies, its shared use may highlight relevant novel interactions between mental state and functional connectome (FC) idiosyncrasy. Using 7T fMRI, we assessed resting-state static and dynamic FCs for 21 Santo Daime members after collective ayahuasca intake in an acute, within-subject study. Here, connectome fingerprinting revealed FCs showed reduced idiosyncrasy, accompanied by a spatiotemporal reallocation of keypoint edges. Importantly, we show that interindividual differences in higher-order FC motifs are relevant to experiential phenotypes, given that they can predict perceptual drug effects. Collectively, our findings offer an example of how individualised connectivity markers can be used to trace a subject's FC across altered states of consciousness. |
| first_indexed | 2024-03-08T15:31:51Z |
| format | Article |
| id | doaj.art-a9d8b103c75e486388e3147bc384b587 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-08T15:31:51Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-a9d8b103c75e486388e3147bc384b5872024-01-10T04:34:55ZengElsevierNeuroImage1095-95722024-01-01285120480Shared functional connectome fingerprints following ritualistic ayahuasca intakePablo Mallaroni0Natasha L. Mason1Lilian Kloft2Johannes T. Reckweg3Kim van Oorsouw4Stefan W. Toennes5Hanna M. Tolle6Enrico Amico7Johannes G. Ramaekers8Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands; Corresponding author.Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the NetherlandsDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the NetherlandsDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the NetherlandsDepartment of Forensic Psychology, Faculty of Psychology and Neuroscience, Maastricht University, the NetherlandsInstitute of Legal Medicine, University Hospital, Goethe University, Frankfurt/Main, GermanyNeuro-X Institute, EPFL, Geneva, SwitzerlandNeuro-X Institute, EPFL, Geneva, SwitzerlandDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the NetherlandsThe knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such “fingerprints” persist under altered states of consciousness is unknown. Ayahuasca is a potent serotonergic psychedelic which produces a widespread dysregulation of functional connectivity. Used communally in religious ceremonies, its shared use may highlight relevant novel interactions between mental state and functional connectome (FC) idiosyncrasy. Using 7T fMRI, we assessed resting-state static and dynamic FCs for 21 Santo Daime members after collective ayahuasca intake in an acute, within-subject study. Here, connectome fingerprinting revealed FCs showed reduced idiosyncrasy, accompanied by a spatiotemporal reallocation of keypoint edges. Importantly, we show that interindividual differences in higher-order FC motifs are relevant to experiential phenotypes, given that they can predict perceptual drug effects. Collectively, our findings offer an example of how individualised connectivity markers can be used to trace a subject's FC across altered states of consciousness.http://www.sciencedirect.com/science/article/pii/S1053811923006304Psychedelics,5-HT2AAyahuascaIndividual differencesConnectome fingerprintsfMRI |
| spellingShingle | Pablo Mallaroni Natasha L. Mason Lilian Kloft Johannes T. Reckweg Kim van Oorsouw Stefan W. Toennes Hanna M. Tolle Enrico Amico Johannes G. Ramaekers Shared functional connectome fingerprints following ritualistic ayahuasca intake NeuroImage Psychedelics,5-HT2A Ayahuasca Individual differences Connectome fingerprints fMRI |
| title | Shared functional connectome fingerprints following ritualistic ayahuasca intake |
| title_full | Shared functional connectome fingerprints following ritualistic ayahuasca intake |
| title_fullStr | Shared functional connectome fingerprints following ritualistic ayahuasca intake |
| title_full_unstemmed | Shared functional connectome fingerprints following ritualistic ayahuasca intake |
| title_short | Shared functional connectome fingerprints following ritualistic ayahuasca intake |
| title_sort | shared functional connectome fingerprints following ritualistic ayahuasca intake |
| topic | Psychedelics,5-HT2A Ayahuasca Individual differences Connectome fingerprints fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923006304 |
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