Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year Study
<b>Purpose:</b> To evaluate the safety and efficacy of Preserflo<sup>®</sup> microshunt implantation in eyes with refractory glaucoma. <b>Methods:</b> In this retrospective study, a cohort of patients who underwent Preserflo<sup>®</sup> microshunt impl...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/23/7086 |
| _version_ | 1797462953096642560 |
|---|---|
| author | Alexandre Majoulet Benjamin Scemla Pascale Hamard Emmanuelle Brasnu Alexandre Hage Christophe Baudouin Antoine Labbé |
| author_facet | Alexandre Majoulet Benjamin Scemla Pascale Hamard Emmanuelle Brasnu Alexandre Hage Christophe Baudouin Antoine Labbé |
| author_sort | Alexandre Majoulet |
| collection | DOAJ |
| description | <b>Purpose:</b> To evaluate the safety and efficacy of Preserflo<sup>®</sup> microshunt implantation in eyes with refractory glaucoma. <b>Methods:</b> In this retrospective study, a cohort of patients who underwent Preserflo<sup>®</sup> microshunt implantation between April 2019 and August 2020 for refractory glaucoma were evaluated. At the time of surgery, all eyes had uncontrolled intraocular pressure (IOP) despite maximally tolerated medical therapy and at least one previous failed glaucoma filtering surgery. The primary outcome was a complete success, defined as postoperative IOP ≤ 21 mm Hg with an IOP reduction ≥ 20% and no repeat filtering surgery. The secondary outcome was qualified success, defined as a complete success with the use of antiglaucoma medications. The rates of needling, bleb repair, and postoperative complications were also recorded. <b>Results:</b> Forty-seven eyes with a mean preoperative IOP of 30.1 ± 7.1 mm Hg and a mean of 3.4 ± 1 glaucoma medications were included. The mean number of previous surgeries prior to microshunt implantation was 2.3 ± 1.3. After 1 year, the mean IOP was significantly reduced to 18.8 ± 4.6 mm Hg, with the mean number of medications significantly reduced to 1.4 ± 1.2. Complete success was achieved in 35% of eyes, and a qualified success in 60% of eyes. A decrease in IOP of at least 30% was found in 55% of eyes. Needling or bleb repair was performed in 49% of eyes. Complications were minimal and transient, except for one eye which presented with tube extrusion, and another eye with a transected tube. A repeat glaucoma surgery had to be performed in 17% of eyes. <b>Conclusions:</b> The Preserflo<sup>®</sup> Microshunt provided moderate success but a significant reduction in IOP, with a good safety profile after one year of follow-up in eyes at high risk for failure of filtering surgery. |
| first_indexed | 2024-03-09T17:43:50Z |
| format | Article |
| id | doaj.art-a9d8c6e8b48e46839532dc08984a8ee2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:43:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a9d8c6e8b48e46839532dc08984a8ee22023-11-24T11:22:40ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011123708610.3390/jcm11237086Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year StudyAlexandre Majoulet0Benjamin Scemla1Pascale Hamard2Emmanuelle Brasnu3Alexandre Hage4Christophe Baudouin5Antoine Labbé6Quinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, INSERM-DHOS CIC 1423, 75012 Paris, FranceDepartment of Ophthalmology, Ambroise Paré Hospital, AP-HP, UVSQ, Paris Saclay University, 91190 Gif-sur-Yvette, FranceQuinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, INSERM-DHOS CIC 1423, 75012 Paris, FranceQuinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, INSERM-DHOS CIC 1423, 75012 Paris, FranceQuinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, INSERM-DHOS CIC 1423, 75012 Paris, FranceQuinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, INSERM-DHOS CIC 1423, 75012 Paris, FranceQuinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, INSERM-DHOS CIC 1423, 75012 Paris, France<b>Purpose:</b> To evaluate the safety and efficacy of Preserflo<sup>®</sup> microshunt implantation in eyes with refractory glaucoma. <b>Methods:</b> In this retrospective study, a cohort of patients who underwent Preserflo<sup>®</sup> microshunt implantation between April 2019 and August 2020 for refractory glaucoma were evaluated. At the time of surgery, all eyes had uncontrolled intraocular pressure (IOP) despite maximally tolerated medical therapy and at least one previous failed glaucoma filtering surgery. The primary outcome was a complete success, defined as postoperative IOP ≤ 21 mm Hg with an IOP reduction ≥ 20% and no repeat filtering surgery. The secondary outcome was qualified success, defined as a complete success with the use of antiglaucoma medications. The rates of needling, bleb repair, and postoperative complications were also recorded. <b>Results:</b> Forty-seven eyes with a mean preoperative IOP of 30.1 ± 7.1 mm Hg and a mean of 3.4 ± 1 glaucoma medications were included. The mean number of previous surgeries prior to microshunt implantation was 2.3 ± 1.3. After 1 year, the mean IOP was significantly reduced to 18.8 ± 4.6 mm Hg, with the mean number of medications significantly reduced to 1.4 ± 1.2. Complete success was achieved in 35% of eyes, and a qualified success in 60% of eyes. A decrease in IOP of at least 30% was found in 55% of eyes. Needling or bleb repair was performed in 49% of eyes. Complications were minimal and transient, except for one eye which presented with tube extrusion, and another eye with a transected tube. A repeat glaucoma surgery had to be performed in 17% of eyes. <b>Conclusions:</b> The Preserflo<sup>®</sup> Microshunt provided moderate success but a significant reduction in IOP, with a good safety profile after one year of follow-up in eyes at high risk for failure of filtering surgery.https://www.mdpi.com/2077-0383/11/23/7086glaucomamicroshuntPreserflorefractory glaucomatrabeculectomy |
| spellingShingle | Alexandre Majoulet Benjamin Scemla Pascale Hamard Emmanuelle Brasnu Alexandre Hage Christophe Baudouin Antoine Labbé Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year Study Journal of Clinical Medicine glaucoma microshunt Preserflo refractory glaucoma trabeculectomy |
| title | Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year Study |
| title_full | Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year Study |
| title_fullStr | Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year Study |
| title_full_unstemmed | Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year Study |
| title_short | Safety and Efficacy of the Preserflo<sup>®</sup> Microshunt in Refractory Glaucoma: A One-Year Study |
| title_sort | safety and efficacy of the preserflo sup r sup microshunt in refractory glaucoma a one year study |
| topic | glaucoma microshunt Preserflo refractory glaucoma trabeculectomy |
| url | https://www.mdpi.com/2077-0383/11/23/7086 |
| work_keys_str_mv | AT alexandremajoulet safetyandefficacyofthepreserflosupsupmicroshuntinrefractoryglaucomaaoneyearstudy AT benjaminscemla safetyandefficacyofthepreserflosupsupmicroshuntinrefractoryglaucomaaoneyearstudy AT pascalehamard safetyandefficacyofthepreserflosupsupmicroshuntinrefractoryglaucomaaoneyearstudy AT emmanuellebrasnu safetyandefficacyofthepreserflosupsupmicroshuntinrefractoryglaucomaaoneyearstudy AT alexandrehage safetyandefficacyofthepreserflosupsupmicroshuntinrefractoryglaucomaaoneyearstudy AT christophebaudouin safetyandefficacyofthepreserflosupsupmicroshuntinrefractoryglaucomaaoneyearstudy AT antoinelabbe safetyandefficacyofthepreserflosupsupmicroshuntinrefractoryglaucomaaoneyearstudy |