Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

Cardiovascular events occur most frequently in the early morning. Similarly, the release of reticulated platelets (RP) by megakaryocytes has a peak in the late night and early morning. Which aspirin regimen most effectively inhibits platelets during these critical hours is unknown. Hence, the primar...

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Bibliographic Details
Main Authors: J.J.K. van Diemen, M.C. Madsen, P. Vrancken, K. de Bie, J.G. van der Bom, G. Veen, T.N. Bonten, W.W. Fuijkschot, Y.M. Smulders, A. Thijs
Format: Article
Language:English
Published: Taylor & Francis Group 2021-08-01
Series:Platelets
Subjects:
aspirin
chronotherapy
circadian rhythm
cross-over trial
platelet aggregation
Online Access:http://dx.doi.org/10.1080/09537104.2020.1809643

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