Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis
Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology. Liver fi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1764 |
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| author | Beatrice Foglia Erica Novo Francesca Protopapa Marina Maggiora Claudia Bocca Stefania Cannito Maurizio Parola |
| author_facet | Beatrice Foglia Erica Novo Francesca Protopapa Marina Maggiora Claudia Bocca Stefania Cannito Maurizio Parola |
| author_sort | Beatrice Foglia |
| collection | DOAJ |
| description | Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology. Liver fibrogenesis and fibrosis, together with chronic inflammatory response, are primarily involved in the progression of chronic liver diseases (CLD). As is well known, a major role in fibrogenesis and fibrosis is played by activated myofibroblasts (MFs), as well as by macrophages and other hepatic cell populations involved in CLD progression. In the present review, we will focus the attention on the emerging pathogenic role of hypoxia, hypoxia-inducible factors (HIFs) and related mediators in the fibrogenic progression of CLD. |
| first_indexed | 2024-03-10T09:43:20Z |
| format | Article |
| id | doaj.art-a9dc16b37df248a4895f964dbfdacaa1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:43:20Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a9dc16b37df248a4895f964dbfdacaa12023-11-22T03:29:42ZengMDPI AGCells2073-44092021-07-01107176410.3390/cells10071764Hypoxia, Hypoxia-Inducible Factors and Liver FibrosisBeatrice Foglia0Erica Novo1Francesca Protopapa2Marina Maggiora3Claudia Bocca4Stefania Cannito5Maurizio Parola6Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyUnit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyUnit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyUnit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyUnit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyUnit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyUnit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyLiver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology. Liver fibrogenesis and fibrosis, together with chronic inflammatory response, are primarily involved in the progression of chronic liver diseases (CLD). As is well known, a major role in fibrogenesis and fibrosis is played by activated myofibroblasts (MFs), as well as by macrophages and other hepatic cell populations involved in CLD progression. In the present review, we will focus the attention on the emerging pathogenic role of hypoxia, hypoxia-inducible factors (HIFs) and related mediators in the fibrogenic progression of CLD.https://www.mdpi.com/2073-4409/10/7/1764hypoxiahypoxia-inducible factorsliver fibrosisliver fibrogenesischronic liver diseases |
| spellingShingle | Beatrice Foglia Erica Novo Francesca Protopapa Marina Maggiora Claudia Bocca Stefania Cannito Maurizio Parola Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis Cells hypoxia hypoxia-inducible factors liver fibrosis liver fibrogenesis chronic liver diseases |
| title | Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis |
| title_full | Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis |
| title_fullStr | Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis |
| title_full_unstemmed | Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis |
| title_short | Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis |
| title_sort | hypoxia hypoxia inducible factors and liver fibrosis |
| topic | hypoxia hypoxia-inducible factors liver fibrosis liver fibrogenesis chronic liver diseases |
| url | https://www.mdpi.com/2073-4409/10/7/1764 |
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