CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation

CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation

Abstract Background Mast cell activation causes degranulation and release of cytokines, thereby promoting inflammation. The aim of this study was to investigate the inhibitory effect of CDK4/6 inhibition on mast cell activation in vitro and in vivo. Methods RBL-2H3 rat basophilic leukemia cells (BLC...

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Bibliographic Details
Main Authors: Yi-Bo Hou, Kunmei Ji, Yue-Tong Sun, Li-Na Zhang, Jia-Jie Chen
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Translational Medicine
Subjects:
Mast cells
Palbociclib
CDK inhibitor
Drug repurposing
Online Access:http://link.springer.com/article/10.1186/s12967-019-2026-9

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