Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics
Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization ba...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/24/8836 |
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| author | Pankaj Singh Prabodh Pandey Shivam Shukla Naren Naik Asima Pradhan |
| author_facet | Pankaj Singh Prabodh Pandey Shivam Shukla Naren Naik Asima Pradhan |
| author_sort | Pankaj Singh |
| collection | DOAJ |
| description | Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data. |
| first_indexed | 2024-03-10T14:10:59Z |
| format | Article |
| id | doaj.art-a9e0280f852e46a6a7206d973f63d7bd |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T14:10:59Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-a9e0280f852e46a6a7206d973f63d7bd2023-11-21T00:11:48ZengMDPI AGApplied Sciences2076-34172020-12-011024883610.3390/app10248836Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer DiagnosticsPankaj Singh0Prabodh Pandey1Shivam Shukla2Naren Naik3Asima Pradhan4Department of Physics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaDepartment of Physics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaCenter for Lasers and Photonics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaCenter for Lasers and Photonics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaDepartment of Physics, Indian Institute of Technology Kanpur, Kanpur 208016, IndiaFiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data.https://www.mdpi.com/2076-3417/10/24/8836optical parametersbeveled fiberspatially resolved reflectanceepithelial pre-cancerlook-up table |
| spellingShingle | Pankaj Singh Prabodh Pandey Shivam Shukla Naren Naik Asima Pradhan Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics Applied Sciences optical parameters beveled fiber spatially resolved reflectance epithelial pre-cancer look-up table |
| title | Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics |
| title_full | Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics |
| title_fullStr | Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics |
| title_full_unstemmed | Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics |
| title_short | Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics |
| title_sort | modelling design and validation of spatially resolved reflectance based fiber optic probe for epithelial precancer diagnostics |
| topic | optical parameters beveled fiber spatially resolved reflectance epithelial pre-cancer look-up table |
| url | https://www.mdpi.com/2076-3417/10/24/8836 |
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