Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient Biomarkers
Nutrient interventions initiated after conception tend to have modest effects on maternal nutritional status and pregnancy outcomes. Thus, we compared the association between micronutrient intakes and the trajectories of their biomarkers before and during pregnancy. Data from a randomized trial of t...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/10/2913 |
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| author | Janina Goletzke Hoang T. Nga Phi N. Quyen Tu Ngu Janet C. King |
| author_facet | Janina Goletzke Hoang T. Nga Phi N. Quyen Tu Ngu Janet C. King |
| author_sort | Janina Goletzke |
| collection | DOAJ |
| description | Nutrient interventions initiated after conception tend to have modest effects on maternal nutritional status and pregnancy outcomes. Thus, we compared the association between micronutrient intakes and the trajectories of their biomarkers before and during pregnancy. Data from a randomized trial of the effect of a nutrient-rich, food-based supplement given to 317 Vietnamese women prior to or during pregnancy on birth outcomes were used to assess nutrient intakes with biomarker trajectories of zinc, iron, folate, cobalamin, and vitamin A using linear mixed regression models. The circulating plasma or serum trajectories of all five micronutrients were associated to their baseline levels (<i>p</i> < 0.0001). Plasma zinc trajectories were also related to farm work (<i>p</i> = 0.024). Cobalamin and vitamin A trajectories were associated with gestational weight gain (<i>p</i> = 0.003 and <i>p</i> = −0.037, respectively). In this population of rural Vietnamese women, nutrient intakes during pregnancy did not affect biomarker trajectories. The primary determinant of each nutrient biomarker trajectory was its respective baseline level prior to conception. |
| first_indexed | 2024-03-10T16:06:54Z |
| format | Article |
| id | doaj.art-a9e0b19b3c5142b8abcee1735fd3b8dd |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:06:54Z |
| publishDate | 2020-09-01 |
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| series | Nutrients |
| spelling | doaj.art-a9e0b19b3c5142b8abcee1735fd3b8dd2023-11-20T14:50:58ZengMDPI AGNutrients2072-66432020-09-011210291310.3390/nu12102913Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient BiomarkersJanina Goletzke0Hoang T. Nga1Phi N. Quyen2Tu Ngu3Janet C. King4Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USANational Institute of Nutrition, Hanoi 100000, VietnamNational Institute of Nutrition, Hanoi 100000, VietnamNational Institute of Nutrition, Hanoi 100000, VietnamDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USANutrient interventions initiated after conception tend to have modest effects on maternal nutritional status and pregnancy outcomes. Thus, we compared the association between micronutrient intakes and the trajectories of their biomarkers before and during pregnancy. Data from a randomized trial of the effect of a nutrient-rich, food-based supplement given to 317 Vietnamese women prior to or during pregnancy on birth outcomes were used to assess nutrient intakes with biomarker trajectories of zinc, iron, folate, cobalamin, and vitamin A using linear mixed regression models. The circulating plasma or serum trajectories of all five micronutrients were associated to their baseline levels (<i>p</i> < 0.0001). Plasma zinc trajectories were also related to farm work (<i>p</i> = 0.024). Cobalamin and vitamin A trajectories were associated with gestational weight gain (<i>p</i> = 0.003 and <i>p</i> = −0.037, respectively). In this population of rural Vietnamese women, nutrient intakes during pregnancy did not affect biomarker trajectories. The primary determinant of each nutrient biomarker trajectory was its respective baseline level prior to conception.https://www.mdpi.com/2072-6643/12/10/2913food-based supplementmicronutrient intakepregnancybiomarker trajectoriesrural Vietnamese women |
| spellingShingle | Janina Goletzke Hoang T. Nga Phi N. Quyen Tu Ngu Janet C. King Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient Biomarkers Nutrients food-based supplement micronutrient intake pregnancy biomarker trajectories rural Vietnamese women |
| title | Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient Biomarkers |
| title_full | Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient Biomarkers |
| title_fullStr | Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient Biomarkers |
| title_full_unstemmed | Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient Biomarkers |
| title_short | Effect of a Nutrient-Rich, Food-Based Supplement Given to Rural Vietnamese Mothers Prior to or during Pregnancy on the Trajectories of Nutrient Biomarkers |
| title_sort | effect of a nutrient rich food based supplement given to rural vietnamese mothers prior to or during pregnancy on the trajectories of nutrient biomarkers |
| topic | food-based supplement micronutrient intake pregnancy biomarker trajectories rural Vietnamese women |
| url | https://www.mdpi.com/2072-6643/12/10/2913 |
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