Deficiency of Integrin β4 Results in Increased Lung Tissue Stiffness and Responds to Substrate Stiffness via Modulating RhoA Activity

Deficiency of Integrin β4 Results in Increased Lung Tissue Stiffness and Responds to Substrate Stiffness via Modulating RhoA Activity

The interaction between extracellular matrix (ECM) and epithelial cells plays a key role in lung development. Our studies found that mice with conditional integrin β4 (ITGB4) knockout presented lung dysplasia and increased stiffness of lung tissues. In accordance with our previous studies regarding...

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Bibliographic Details
Main Authors: Yinxiu Chi, Yu Chen, Wang Jiang, Wenjie Huang, Mingxing Ouyang, Lei Liu, Yan Pan, Jingjing Li, Xiangping Qu, Huijun Liu, Chi Liu, Linhong Deng, Xiaoqun Qin, Yang Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
integrinβ4
lung stiffness
lysyl oxidase-like 4
collagen VI
RhoA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.845440/full

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