Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy
Fucoidans, discovered in 1913, are fucose-rich sulfated polysaccharides extracted mainly from brown seaweed. These versatile and nontoxic marine-origin heteropolysaccharides have a wide range of favorable biological activities, including antitumor, immunomodulatory, antiviral, antithrombotic, antico...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/2/128 |
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| author | Yani Li Eileen McGowan Size Chen Jerran Santos Haibin Yin Yiguang Lin |
| author_facet | Yani Li Eileen McGowan Size Chen Jerran Santos Haibin Yin Yiguang Lin |
| author_sort | Yani Li |
| collection | DOAJ |
| description | Fucoidans, discovered in 1913, are fucose-rich sulfated polysaccharides extracted mainly from brown seaweed. These versatile and nontoxic marine-origin heteropolysaccharides have a wide range of favorable biological activities, including antitumor, immunomodulatory, antiviral, antithrombotic, anticoagulant, antithrombotic, antioxidant, and lipid-lowering activities. In the early 1980s, fucoidans were first recognized for their role in supporting the immune response and later, in the 1990s, their effects on immune potentiation began to emerge. In recent years, the understanding of the immunomodulatory effects of fucoidan has expanded significantly. The ability of fucoidan(s) to activate CTL-mediated cytotoxicity against cancer cells, strong antitumor property, and robust safety profile make fucoidans desirable for effective cancer immunotherapy. This review focusses on current progress and understanding of the immunopotentiation activity of various fucoidans, emphasizing their relevance to cancer immunotherapy. Here, we will discuss the action of fucoidans in different immune cells and review how fucoidans can be used as adjuvants in conjunction with immunotherapeutic products to improve cancer treatment and clinical outcome. Some key rationales for the possible combination of fucoidans with immunotherapy will be discussed. An update is provided on human clinical studies and available registered cancer clinical trials using fucoidans while highlighting future prospects and challenges. |
| first_indexed | 2024-03-11T08:30:40Z |
| format | Article |
| id | doaj.art-a9e185a3c0cd4cb998421deb35d6bfd5 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T08:30:40Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a9e185a3c0cd4cb998421deb35d6bfd52023-11-16T21:48:10ZengMDPI AGMarine Drugs1660-33972023-02-0121212810.3390/md21020128Immunopotentiating Activity of Fucoidans and Relevance to Cancer ImmunotherapyYani Li0Eileen McGowan1Size Chen2Jerran Santos3Haibin Yin4Yiguang Lin5School of Life Science, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, NSW 2007, AustraliaSchool of Life Science, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, NSW 2007, AustraliaDepartment of Immuno-Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, ChinaAdvanced Tissue Engineering and Stem Cell Biology Group, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, NSW 2007, AustraliaResearch & Development Division, Guangzhou Anjie Biomedical Technology Co., Limited, Guangzhou 510535, ChinaSchool of Life Science, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, NSW 2007, AustraliaFucoidans, discovered in 1913, are fucose-rich sulfated polysaccharides extracted mainly from brown seaweed. These versatile and nontoxic marine-origin heteropolysaccharides have a wide range of favorable biological activities, including antitumor, immunomodulatory, antiviral, antithrombotic, anticoagulant, antithrombotic, antioxidant, and lipid-lowering activities. In the early 1980s, fucoidans were first recognized for their role in supporting the immune response and later, in the 1990s, their effects on immune potentiation began to emerge. In recent years, the understanding of the immunomodulatory effects of fucoidan has expanded significantly. The ability of fucoidan(s) to activate CTL-mediated cytotoxicity against cancer cells, strong antitumor property, and robust safety profile make fucoidans desirable for effective cancer immunotherapy. This review focusses on current progress and understanding of the immunopotentiation activity of various fucoidans, emphasizing their relevance to cancer immunotherapy. Here, we will discuss the action of fucoidans in different immune cells and review how fucoidans can be used as adjuvants in conjunction with immunotherapeutic products to improve cancer treatment and clinical outcome. Some key rationales for the possible combination of fucoidans with immunotherapy will be discussed. An update is provided on human clinical studies and available registered cancer clinical trials using fucoidans while highlighting future prospects and challenges.https://www.mdpi.com/1660-3397/21/2/128fucoidanseaweedimmunopotentiationimmunomodulatoryimmunotherapycancer treatment |
| spellingShingle | Yani Li Eileen McGowan Size Chen Jerran Santos Haibin Yin Yiguang Lin Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy Marine Drugs fucoidan seaweed immunopotentiation immunomodulatory immunotherapy cancer treatment |
| title | Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy |
| title_full | Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy |
| title_fullStr | Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy |
| title_full_unstemmed | Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy |
| title_short | Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy |
| title_sort | immunopotentiating activity of fucoidans and relevance to cancer immunotherapy |
| topic | fucoidan seaweed immunopotentiation immunomodulatory immunotherapy cancer treatment |
| url | https://www.mdpi.com/1660-3397/21/2/128 |
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