Stability of motor-nonmotor subtype in early-stage Parkinson’s disease
BackgroundThe different clinical characteristics and prognostic values of the motor-nonmotor subtypes of Parkinson’s disease (PD) have been established by previous studies. However, the consistency of motor-nonmotor subtypes in patients with early-stage Parkinson’s disease required further investiga...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1040405/full |
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| author | Yi Xiao Qianqian Wei Ruwei Ou Yanbing Hou Lingyu Zhang Kuncheng Liu Junyu Lin Tianmi Yang Qirui Jiang Huifang Shang |
| author_facet | Yi Xiao Qianqian Wei Ruwei Ou Yanbing Hou Lingyu Zhang Kuncheng Liu Junyu Lin Tianmi Yang Qirui Jiang Huifang Shang |
| author_sort | Yi Xiao |
| collection | DOAJ |
| description | BackgroundThe different clinical characteristics and prognostic values of the motor-nonmotor subtypes of Parkinson’s disease (PD) have been established by previous studies. However, the consistency of motor-nonmotor subtypes in patients with early-stage Parkinson’s disease required further investigation. The present study aimed to evaluate the consistency of motor-nonmotor subtypes across five years of follow-up in a longitudinal cohort.Materials and methodsPatients were classified into different subtypes (mild-motor–predominant, intermediate, diffuse malignant; or tremor-dominant, indeterminate, postural instability and gait difficulty) according to previously verified motor-nonmotor and motor subtyping methods at baseline and at every year of follow-up. The agreement between subtypes was examined using Cohen’s kappa and total agreement. The determinants of having the diffuse malignant subtype as of the fifth-year visit were explored using logistic regression.ResultsA total of 421 patients were included. There was a fair degree of agreement between the baseline motor-nonmotor subtype and the subtype recorded at the one-year follow-up visit (κ = 0.30 ± 0.09; total agreement, 60.6%) and at following years’ visits. The motor-nonmotor subtype had a lower agreement between baseline and follow-up than did the motor subtype. The baseline motor-nonmotor subtype was the determinant of diffuse malignant subtype at the fifth-year visit.ConclusionMany patients experienced a change in their motor-nonmotor subtype during follow-up. Further studies of consistency in PD subtyping methods should be conducted in the future. |
| first_indexed | 2024-04-12T11:10:20Z |
| format | Article |
| id | doaj.art-a9e6a06c753145c7af97d6e8c5a0304d |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T11:10:20Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a9e6a06c753145c7af97d6e8c5a0304d2022-12-22T03:35:38ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10404051040405Stability of motor-nonmotor subtype in early-stage Parkinson’s diseaseYi Xiao0Qianqian Wei1Ruwei Ou2Yanbing Hou3Lingyu Zhang4Kuncheng Liu5Junyu Lin6Tianmi Yang7Qirui Jiang8Huifang Shang9Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaHealth Management Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaBackgroundThe different clinical characteristics and prognostic values of the motor-nonmotor subtypes of Parkinson’s disease (PD) have been established by previous studies. However, the consistency of motor-nonmotor subtypes in patients with early-stage Parkinson’s disease required further investigation. The present study aimed to evaluate the consistency of motor-nonmotor subtypes across five years of follow-up in a longitudinal cohort.Materials and methodsPatients were classified into different subtypes (mild-motor–predominant, intermediate, diffuse malignant; or tremor-dominant, indeterminate, postural instability and gait difficulty) according to previously verified motor-nonmotor and motor subtyping methods at baseline and at every year of follow-up. The agreement between subtypes was examined using Cohen’s kappa and total agreement. The determinants of having the diffuse malignant subtype as of the fifth-year visit were explored using logistic regression.ResultsA total of 421 patients were included. There was a fair degree of agreement between the baseline motor-nonmotor subtype and the subtype recorded at the one-year follow-up visit (κ = 0.30 ± 0.09; total agreement, 60.6%) and at following years’ visits. The motor-nonmotor subtype had a lower agreement between baseline and follow-up than did the motor subtype. The baseline motor-nonmotor subtype was the determinant of diffuse malignant subtype at the fifth-year visit.ConclusionMany patients experienced a change in their motor-nonmotor subtype during follow-up. Further studies of consistency in PD subtyping methods should be conducted in the future.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1040405/fullfollow-up studies (MeSH)Parkinson’s diseaseprognosissubtypestability |
| spellingShingle | Yi Xiao Qianqian Wei Ruwei Ou Yanbing Hou Lingyu Zhang Kuncheng Liu Junyu Lin Tianmi Yang Qirui Jiang Huifang Shang Stability of motor-nonmotor subtype in early-stage Parkinson’s disease Frontiers in Aging Neuroscience follow-up studies (MeSH) Parkinson’s disease prognosis subtype stability |
| title | Stability of motor-nonmotor subtype in early-stage Parkinson’s disease |
| title_full | Stability of motor-nonmotor subtype in early-stage Parkinson’s disease |
| title_fullStr | Stability of motor-nonmotor subtype in early-stage Parkinson’s disease |
| title_full_unstemmed | Stability of motor-nonmotor subtype in early-stage Parkinson’s disease |
| title_short | Stability of motor-nonmotor subtype in early-stage Parkinson’s disease |
| title_sort | stability of motor nonmotor subtype in early stage parkinson s disease |
| topic | follow-up studies (MeSH) Parkinson’s disease prognosis subtype stability |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1040405/full |
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