Two Toxoplasma gondii putative pore-forming proteins, GRA47 and GRA72, influence small molecule permeability of the parasitophorous vacuole

Two Toxoplasma gondii putative pore-forming proteins, GRA47 and GRA72, influence small molecule permeability of the parasitophorous vacuole

ABSTRACTToxoplasma gondii, a medically important intracellular parasite, uses GRA proteins secreted from dense granule organelles to mediate nutrient flux across the parasitophorous vacuole membrane (PVM). GRA17 and GRA23 are known pore-forming proteins on the PVM involved in this process, but the r...

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Bibliographic Details
Main Authors: Mebratu A. Bitew, Pablo S. Gaete, Christopher Swale, Parag Maru, Jorge E. Contreras, Jeroen P. J. Saeij
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
Toxoplasma gondii
GRA47
GRA72
pore
pore-lining histidine
Xenopus oocytes
Online Access:https://journals.asm.org/doi/10.1128/mbio.03081-23

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