Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17

Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17

Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family are major mediators of ectodomain shedding. ADAM17 is involved in the processing of multiple substrates including tumor necrosis factor (TNF)...

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Bibliographic Details
Main Authors: Miryam Müller, Claire Saunders, Anke Senftleben, Johannes P. W. Heidbuechel, Birgit Halwachs, Julia Bolik, Nina Hedemann, Christian Röder, Dirk Bauerschlag, Stefan Rose-John, Dirk Schmidt-Arras
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
proteases
tetraspanin
TNF
inflammation
Online Access:https://www.mdpi.com/2073-4409/11/17/2683

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